IDH2 somatic mutations in chronic myeloid leukemia patients in blast crisis

Soverini, S., Score, J., Iacobucci, I., Poerio, A., Lonetti, A., Gnani, A., Colarossi, S., Ferrari, A., Castagnetti, F., Rosti, G., Cervantes, F., Hochhaus, A., Delledonne, M., Ferrarini, A., Sazzini, M., Luiselli, D., Baccarani, M., Cross, N.C.P. and Martinelli, G. (2011) IDH2 somatic mutations in chronic myeloid leukemia patients in blast crisis. Leukemia, 25 (1), 178-181. (doi:10.1038/leu.2010.236).

Abstract

We read with interest a series of manuscripts,1, 2, 3, 4, 5, 6 reporting somatic mutations of the isocitrate dehydrogenase 1 and 2 enzyme isoforms (IDH1, IDH2) in patients with de novo acute myeloid leukemia (AML), in patients with chronic and blast phase Philadelphia chromosome-negative (Ph–) myeloproliferative neoplasms (MPNs) and in patients with early and accelerated phase myelodysplastic syndromes (MDSs).We have recently screened, by massively parallel sequencing, the transcriptome of a Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) patient

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Contributors

Author: N.C.P. Cross

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