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CtBPs promote mitotic fidelity through their activities in the cell nucleus

CtBPs promote mitotic fidelity through their activities in the cell nucleus
CtBPs promote mitotic fidelity through their activities in the cell nucleus
CtBPs form NADH-sensitive chromatin-modifying complexes, which link cellular metabolism to gene transcription. They also function in the cytoplasm to regulate Golgi fissioning; their inhibition can consequently cause a Golgi-dependent checkpoint in G(2). We have recently identified a novel role of CtBPs in the maintenance of mitotic fidelity; inhibition of CtBP synthesis resulting in reduced association of aurora B with mitotic chromatin and aberrant segregation of chromosomes. Here, we demonstrate that it is the interaction of CtBPs with transcriptional regulators and/or chromatin-modifying enzymes in the cell nucleus, rather than their role in Golgi fission, which is critical for the maintenance of mitotic fidelity
aurora B, CtBP proteins, BARS, mitosis, transcriptional repressor
0950-9232
1271-1280
Birts, C N
8689ddad-ba47-4ca6-82c5-001315dbd250
Bergman, L M
d2c8c77f-4471-4277-9e34-b3a4a025dea1
Blaydes, J P
e957f999-fd91-4f77-ad62-5b4ef069b15b
Birts, C N
8689ddad-ba47-4ca6-82c5-001315dbd250
Bergman, L M
d2c8c77f-4471-4277-9e34-b3a4a025dea1
Blaydes, J P
e957f999-fd91-4f77-ad62-5b4ef069b15b

Birts, C N, Bergman, L M and Blaydes, J P (2011) CtBPs promote mitotic fidelity through their activities in the cell nucleus. Oncogene, 30, 1271-1280. (doi:10.1038/onc.2010.507). (PMID:21057548)

Record type: Article

Abstract

CtBPs form NADH-sensitive chromatin-modifying complexes, which link cellular metabolism to gene transcription. They also function in the cytoplasm to regulate Golgi fissioning; their inhibition can consequently cause a Golgi-dependent checkpoint in G(2). We have recently identified a novel role of CtBPs in the maintenance of mitotic fidelity; inhibition of CtBP synthesis resulting in reduced association of aurora B with mitotic chromatin and aberrant segregation of chromosomes. Here, we demonstrate that it is the interaction of CtBPs with transcriptional regulators and/or chromatin-modifying enzymes in the cell nucleus, rather than their role in Golgi fission, which is critical for the maintenance of mitotic fidelity

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More information

Published date: 2011
Keywords: aurora B, CtBP proteins, BARS, mitosis, transcriptional repressor
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 167213
URI: https://eprints.soton.ac.uk/id/eprint/167213
ISSN: 0950-9232
PURE UUID: 4e0d0e56-38f2-4d57-aa0b-b5b70783eb45
ORCID for C N Birts: ORCID iD orcid.org/0000-0002-0368-8766
ORCID for J P Blaydes: ORCID iD orcid.org/0000-0001-8525-0209

Catalogue record

Date deposited: 10 Nov 2010 09:17
Last modified: 20 Jul 2019 01:06

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