The enhancement of contextual fear conditioning by ABT-418
The enhancement of contextual fear conditioning by ABT-418
Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.
246-9
Kenney, Justin W.
a498bbd6-750d-4778-bd72-6ea336c883e8
Wilkinson, Derek S.
6f3b2ddb-70ec-48e8-b29e-28eab85231c0
Gould, Thomas J.
de84ac91-2b6f-4524-b4d3-1f210047c57a
May 2010
Kenney, Justin W.
a498bbd6-750d-4778-bd72-6ea336c883e8
Wilkinson, Derek S.
6f3b2ddb-70ec-48e8-b29e-28eab85231c0
Gould, Thomas J.
de84ac91-2b6f-4524-b4d3-1f210047c57a
Abstract
Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.
This record has no associated files available for download.
More information
Published date: May 2010
Identifiers
Local EPrints ID: 168295
URI: http://eprints.soton.ac.uk/id/eprint/168295
ISSN: 0955-8810
PURE UUID: 28e69bce-f1a7-443a-a107-587e933a931d
Catalogue record
Date deposited: 30 Nov 2010 15:35
Last modified: 14 Mar 2024 02:17
Export record
Altmetrics
Contributors
Author:
Justin W. Kenney
Author:
Derek S. Wilkinson
Author:
Thomas J. Gould
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics