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The enhancement of contextual fear conditioning by ABT-418

Record type: Article

Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.

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Citation

Kenney, Justin W., Wilkinson, Derek S. and Gould, Thomas J. (2010) The enhancement of contextual fear conditioning by ABT-418 Behavioural Pharmacology, 21, (3), pp. 246-9. (doi:10.1097/FBP.0b013e32833a5b9d). (PMID:20400893).

More information

Published date: May 2010

Identifiers

Local EPrints ID: 168295
URI: http://eprints.soton.ac.uk/id/eprint/168295
ISSN: 0955-8810
PURE UUID: 28e69bce-f1a7-443a-a107-587e933a931d

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Date deposited: 30 Nov 2010 15:35
Last modified: 18 Jul 2017 12:23

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Author: Justin W. Kenney
Author: Derek S. Wilkinson
Author: Thomas J. Gould

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