The enhancement of contextual fear conditioning by ABT-418

Kenney, Justin W., Wilkinson, Derek S. and Gould, Thomas J. (2010) The enhancement of contextual fear conditioning by ABT-418 Behavioural Pharmacology, 21, (3), pp. 246-9. (doi:10.1097/FBP.0b013e32833a5b9d). (PMID:20400893).


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Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1097/FBP.0b013e32833a5b9d
ISSNs: 0955-8810 (print)

ePrint ID: 168295
Date :
Date Event
May 2010Published
Date Deposited: 30 Nov 2010 15:35
Last Modified: 18 Apr 2017 03:33
Further Information:Google Scholar

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