The role of glia in protein misfolding diseases

Samson, Ben (2010) The role of glia in protein misfolding diseases University of Southampton, School of Biological Sciences, Masters Thesis , 83pp.


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The astrocytes, oligodendrocytes and microglia make up a significant proportion of the cells of the CNS. In recent years, there has been a burgeoning interest in the role of glial cells, in neurodegenerative disease. These cell types have been shown to play diverse roles in neuroinflammation, bioenergetics, signalling and intracellular oxidative balance, amongst others. Studies on Parkinson's, Alzheimer's, Huntington's and prion diseases suggest that the misfolded intra- or extra-cellular proteins that characterize these diseases could interfere with glial cell functions. I have developed and characterized an in vitro astrocyte primary cell culture. I have used this to look at the changes in glial glutamate transporter levels in the presence of mutant htt and to conduct a set of calcium experiments. These experiments provide essential tools for future studies into glial biology in neurodegeneration.

Item Type: Thesis (Masters)

Organisations: University of Southampton
ePrint ID: 168311
Date :
Date Event
1 June 2010Published
Date Deposited: 03 Dec 2010 16:08
Last Modified: 18 Apr 2017 03:33
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