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Differential suppression of tumor-specific CD8+ T cells by regulatory T cells

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In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8(+) CTLs. Other schedules for inducing immunity to CT26 have been described, but they do not lead to cross-protection. We show that Treg ablation facilitates the development of new CTL specificities that are normally cryptic, and have mapped the root epitope of one of these responses. This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes.

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James, Edward, Yeh, Alex, King, Cathy, Korangy, Firouzeh, Bailey, Ian, Boulanger, Denise S., Van den Eynde, Benoît J., Murray, Nicholas and Elliott, Tim J. (2010) Differential suppression of tumor-specific CD8+ T cells by regulatory T cells Journal of Immunology, 185, (9), pp. 5048-5055. (doi:10.4049/?jimmunol.1000134). (PMID:20921533).

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Published date: 1 November 2010
Organisations: Cancer Sciences


Local EPrints ID: 168555
ISSN: 0022-1767
PURE UUID: 49e97f47-6e46-41bc-aa2a-b5412d2c1974
ORCID for Tim J. Elliott: ORCID iD

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Date deposited: 30 Nov 2010 14:02
Last modified: 18 Jul 2017 12:20

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Author: Edward James
Author: Alex Yeh
Author: Cathy King
Author: Firouzeh Korangy
Author: Ian Bailey
Author: Denise S. Boulanger
Author: Benoît J. Van den Eynde
Author: Nicholas Murray
Author: Tim J. Elliott ORCID iD

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