Differential suppression of tumor-specific CD8+ T cells by regulatory T cells
James, Edward, Yeh, Alex, King, Cathy, Korangy, Firouzeh, Bailey, Ian, Boulanger, Denise S., Van den Eynde, Benoît J., Murray, Nicholas and Elliott, Tim J. (2010) Differential suppression of tumor-specific CD8+ T cells by regulatory T cells Journal of Immunology, 185, (9), pp. 5048-5055. (doi:10.4049/?jimmunol.1000134). (PMID:20921533).
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In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8(+) CTLs. Other schedules for inducing immunity to CT26 have been described, but they do not lead to cross-protection. We show that Treg ablation facilitates the development of new CTL specificities that are normally cryptic, and have mapped the root epitope of one of these responses. This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes.
|Digital Object Identifier (DOI):||doi:10.4049/?jimmunol.1000134|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
|Date Deposited:||30 Nov 2010 14:02|
|Last Modified:||23 Feb 2017 19:03|
Funded by: CRUK (UNSPECIFIED)
UNSPECIFIED to UNSPECIFIED
|Further Information:||Google Scholar|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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