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Differential suppression of tumor-specific CD8+ T cells by regulatory T cells

Differential suppression of tumor-specific CD8+ T cells by regulatory T cells
Differential suppression of tumor-specific CD8+ T cells by regulatory T cells
In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8(+) CTLs. Other schedules for inducing immunity to CT26 have been described, but they do not lead to cross-protection. We show that Treg ablation facilitates the development of new CTL specificities that are normally cryptic, and have mapped the root epitope of one of these responses. This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes.
0022-1767
5048-5055
James, Edward
7dc1afb7-d326-4050-89fc-1f4e2a1a19a4
Yeh, Alex
507b134b-d5d6-4ed1-bd8c-5c7354771ed9
King, Cathy
1c5a5057-db7b-48ef-bffb-3618e25837d4
Korangy, Firouzeh
71904c44-e3ab-4998-955a-60aac1ea4362
Bailey, Ian
e659068f-e591-4185-afd1-5e19a5794bda
Boulanger, Denise S.
c226ad99-9c9a-485a-b480-42fb8799120f
Van den Eynde, Benoît J.
9df2e2f1-d2c5-4210-8c81-f17c1cb2df73
Murray, Nicholas
181c1b77-e1d3-4fa5-9ef8-52c73025ab9d
Elliott, Tim J.
16670fa8-c2f9-477a-91df-7c9e5b453e0e
James, Edward
7dc1afb7-d326-4050-89fc-1f4e2a1a19a4
Yeh, Alex
507b134b-d5d6-4ed1-bd8c-5c7354771ed9
King, Cathy
1c5a5057-db7b-48ef-bffb-3618e25837d4
Korangy, Firouzeh
71904c44-e3ab-4998-955a-60aac1ea4362
Bailey, Ian
e659068f-e591-4185-afd1-5e19a5794bda
Boulanger, Denise S.
c226ad99-9c9a-485a-b480-42fb8799120f
Van den Eynde, Benoît J.
9df2e2f1-d2c5-4210-8c81-f17c1cb2df73
Murray, Nicholas
181c1b77-e1d3-4fa5-9ef8-52c73025ab9d
Elliott, Tim J.
16670fa8-c2f9-477a-91df-7c9e5b453e0e

James, Edward, Yeh, Alex, King, Cathy, Korangy, Firouzeh, Bailey, Ian, Boulanger, Denise S., Van den Eynde, Benoît J., Murray, Nicholas and Elliott, Tim J. (2010) Differential suppression of tumor-specific CD8+ T cells by regulatory T cells Journal of Immunology, 185, (9), pp. 5048-5055. (doi:10.4049/?jimmunol.1000134). (PMID:20921533).

Record type: Article

Abstract

In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8(+) CTLs. Other schedules for inducing immunity to CT26 have been described, but they do not lead to cross-protection. We show that Treg ablation facilitates the development of new CTL specificities that are normally cryptic, and have mapped the root epitope of one of these responses. This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes.

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Published date: 1 November 2010
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 168555
URI: http://eprints.soton.ac.uk/id/eprint/168555
ISSN: 0022-1767
PURE UUID: 49e97f47-6e46-41bc-aa2a-b5412d2c1974
ORCID for Tim J. Elliott: ORCID iD orcid.org/0000-0003-1097-0222

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Date deposited: 30 Nov 2010 14:02
Last modified: 18 Jul 2017 12:20

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Contributors

Author: Edward James
Author: Alex Yeh
Author: Cathy King
Author: Firouzeh Korangy
Author: Ian Bailey
Author: Denise S. Boulanger
Author: Benoît J. Van den Eynde
Author: Nicholas Murray
Author: Tim J. Elliott ORCID iD

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