Preterm birth - a risk factor for type 2 diabetes? The Helsinki Birth Cohort Study
Preterm birth - a risk factor for type 2 diabetes? The Helsinki Birth Cohort Study
Objective: the association between low birth weight and type 2 diabetes is well established. We studied whether preterm birth carries a similar risk.
Research design and methods: the Helsinki Birth Cohort includes 13,345 men and women born between 1934 and 1944. Of them, 12,813 had adequate data on length of gestation, which we linked with data on special reimbursement for diabetes medication.
Results: of the subjects, 5.1% had received special reimbursement after age 40. In subjects born before 35 weeks of gestation, the odds ratio for diabetes was 1.68 (95% CI 1.06–2.65) compared with that in those born at term. After adjustment for birth weight relative to length of gestation, the odds ratio was 1.59 (1.00–2.52).
Conclusions: preterm birth before 35 weeks of gestation is associated with an increased risk of type 2 diabetes in adult life. The risk is independent of that associated with slow fetal growth
2623-2625
Kajantie, E
91d7b573-d5c0-45cb-9535-2d2beb1d2888
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
December 2010
Kajantie, E
91d7b573-d5c0-45cb-9535-2d2beb1d2888
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Kajantie, E, Osmond, C., Barker, D.J. and Eriksson, J.G.
(2010)
Preterm birth - a risk factor for type 2 diabetes? The Helsinki Birth Cohort Study.
Diabetes Care, 33 (12), .
(doi:10.2337/dc10-0912).
(PMID:20823347)
Abstract
Objective: the association between low birth weight and type 2 diabetes is well established. We studied whether preterm birth carries a similar risk.
Research design and methods: the Helsinki Birth Cohort includes 13,345 men and women born between 1934 and 1944. Of them, 12,813 had adequate data on length of gestation, which we linked with data on special reimbursement for diabetes medication.
Results: of the subjects, 5.1% had received special reimbursement after age 40. In subjects born before 35 weeks of gestation, the odds ratio for diabetes was 1.68 (95% CI 1.06–2.65) compared with that in those born at term. After adjustment for birth weight relative to length of gestation, the odds ratio was 1.59 (1.00–2.52).
Conclusions: preterm birth before 35 weeks of gestation is associated with an increased risk of type 2 diabetes in adult life. The risk is independent of that associated with slow fetal growth
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Published date: December 2010
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Local EPrints ID: 169155
URI: http://eprints.soton.ac.uk/id/eprint/169155
ISSN: 1935-5548
PURE UUID: d1195bba-a029-4782-b5e7-e46d64217862
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Date deposited: 13 Dec 2010 08:38
Last modified: 14 Mar 2024 02:38
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Author:
E Kajantie
Author:
D.J. Barker
Author:
J.G. Eriksson
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