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The effect of hip and knee arthroplasty on oral anti-inflammatory use and the relationship to body mass index: results from the UK general practice research database

Record type: Article

Objective: To determine the use of oral anti-inflammatory drugs in the year before and the 2 years after primary total hip (THR) or knee (TKR) replacement, and whether this varies according to Body mass Index (BMI).

Design: 28,068 THR’s and 24,364 TKR’s, with five matched controls per case were identified from the General Practitioner Research Database. Anti-inflammatory usage was categorized into “zero coverage” – no prescribed anti-inflammatory medication and “>80% coverage” – prescribed anti-inflammatory medication for greater than 80% of the days in the year. Secondary subset analysis was performed according to BMI.

Results: 1 year post-surgery the proportion of cases on >80% coverage reduced from 21% (95%confidence interval (CI): 20–22%) to 8% (95%CI: 7–10%) for THR and 21% (95%CI: 20–22%) to 13% (95%CI: 11–14%) for TKR, with no ongoing reduction at 2 years. Zero coverage increased at one and both time points. The proportion of THR’s on >80% coverage increased with BMI pre-op. The magnitude in reduction post-op was similar across all BMI groups. The proportion of TKR’s on >80% coverage pre-op was greatest in extreme BMI categories. The magnitude in reduction post-op was similar across all BMI groups.

Conclusion: THR/TKR’s reduce the need for anti-inflammatory medication with most benefit observed in the first post-operative year. Increasing BMI affects anti-inflammatory use both in the general population and those undergoing THR/TKR surgery but without strong evidence of a detrimental effect on the benefits of pain relief.

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Citation

Bolland, B.J.R.F., Maskell, J., Latham, J.M., Dunlop, D.G. and Arden, N.K. (2011) The effect of hip and knee arthroplasty on oral anti-inflammatory use and the relationship to body mass index: results from the UK general practice research database Osteoarthritis and Cartilage, 19, (1), pp. 29-36. (doi:10.1016/j.joca.2010.10.012). (PMID:21034838).

More information

Published date: January 2011
Keywords: nsaid, hip, knee, arthroplasty
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 170329
URI: http://eprints.soton.ac.uk/id/eprint/170329
ISSN: 1063-4584
PURE UUID: 128d6262-720f-4a10-ad1e-1c599c081511

Catalogue record

Date deposited: 05 Jan 2011 12:38
Last modified: 18 Jul 2017 12:17

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Contributors

Author: B.J.R.F. Bolland
Author: J. Maskell
Author: J.M. Latham
Author: D.G. Dunlop
Author: N.K. Arden

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