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The effect of hip and knee arthroplasty on oral anti-inflammatory use and the relationship to body mass index: results from the UK general practice research database

The effect of hip and knee arthroplasty on oral anti-inflammatory use and the relationship to body mass index: results from the UK general practice research database
The effect of hip and knee arthroplasty on oral anti-inflammatory use and the relationship to body mass index: results from the UK general practice research database
Objective: To determine the use of oral anti-inflammatory drugs in the year before and the 2 years after primary total hip (THR) or knee (TKR) replacement, and whether this varies according to Body mass Index (BMI).

Design: 28,068 THR’s and 24,364 TKR’s, with five matched controls per case were identified from the General Practitioner Research Database. Anti-inflammatory usage was categorized into “zero coverage” – no prescribed anti-inflammatory medication and “>80% coverage” – prescribed anti-inflammatory medication for greater than 80% of the days in the year. Secondary subset analysis was performed according to BMI.

Results: 1 year post-surgery the proportion of cases on >80% coverage reduced from 21% (95%confidence interval (CI): 20–22%) to 8% (95%CI: 7–10%) for THR and 21% (95%CI: 20–22%) to 13% (95%CI: 11–14%) for TKR, with no ongoing reduction at 2 years. Zero coverage increased at one and both time points. The proportion of THR’s on >80% coverage increased with BMI pre-op. The magnitude in reduction post-op was similar across all BMI groups. The proportion of TKR’s on >80% coverage pre-op was greatest in extreme BMI categories. The magnitude in reduction post-op was similar across all BMI groups.

Conclusion: THR/TKR’s reduce the need for anti-inflammatory medication with most benefit observed in the first post-operative year. Increasing BMI affects anti-inflammatory use both in the general population and those undergoing THR/TKR surgery but without strong evidence of a detrimental effect on the benefits of pain relief.
nsaid, hip, knee, arthroplasty
1063-4584
29-36
Bolland, B.J.R.F.
c23b9b00-bc30-437a-b1db-7002f64a7d5f
Culliford, D.J.
25511573-74d3-422a-b0ee-dfe60f80df87
Maskell, J.
7edffaec-77e7-49e6-9bd8-d1a98af01185
Latham, J.M.
c16a0f2e-dd8f-470d-b0e5-8914e46ac00e
Dunlop, D.G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Bolland, B.J.R.F.
c23b9b00-bc30-437a-b1db-7002f64a7d5f
Culliford, D.J.
25511573-74d3-422a-b0ee-dfe60f80df87
Maskell, J.
7edffaec-77e7-49e6-9bd8-d1a98af01185
Latham, J.M.
c16a0f2e-dd8f-470d-b0e5-8914e46ac00e
Dunlop, D.G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f

Bolland, B.J.R.F., Culliford, D.J., Maskell, J., Latham, J.M., Dunlop, D.G. and Arden, N.K. (2011) The effect of hip and knee arthroplasty on oral anti-inflammatory use and the relationship to body mass index: results from the UK general practice research database. Osteoarthritis and Cartilage, 19 (1), 29-36. (doi:10.1016/j.joca.2010.10.012). (PMID:21034838)

Record type: Article

Abstract

Objective: To determine the use of oral anti-inflammatory drugs in the year before and the 2 years after primary total hip (THR) or knee (TKR) replacement, and whether this varies according to Body mass Index (BMI).

Design: 28,068 THR’s and 24,364 TKR’s, with five matched controls per case were identified from the General Practitioner Research Database. Anti-inflammatory usage was categorized into “zero coverage” – no prescribed anti-inflammatory medication and “>80% coverage” – prescribed anti-inflammatory medication for greater than 80% of the days in the year. Secondary subset analysis was performed according to BMI.

Results: 1 year post-surgery the proportion of cases on >80% coverage reduced from 21% (95%confidence interval (CI): 20–22%) to 8% (95%CI: 7–10%) for THR and 21% (95%CI: 20–22%) to 13% (95%CI: 11–14%) for TKR, with no ongoing reduction at 2 years. Zero coverage increased at one and both time points. The proportion of THR’s on >80% coverage increased with BMI pre-op. The magnitude in reduction post-op was similar across all BMI groups. The proportion of TKR’s on >80% coverage pre-op was greatest in extreme BMI categories. The magnitude in reduction post-op was similar across all BMI groups.

Conclusion: THR/TKR’s reduce the need for anti-inflammatory medication with most benefit observed in the first post-operative year. Increasing BMI affects anti-inflammatory use both in the general population and those undergoing THR/TKR surgery but without strong evidence of a detrimental effect on the benefits of pain relief.

Full text not available from this repository.

More information

Published date: January 2011
Keywords: nsaid, hip, knee, arthroplasty
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 170329
URI: https://eprints.soton.ac.uk/id/eprint/170329
ISSN: 1063-4584
PURE UUID: 128d6262-720f-4a10-ad1e-1c599c081511

Catalogue record

Date deposited: 05 Jan 2011 12:38
Last modified: 16 Jul 2019 23:48

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