Synthesis and evaluation of amino-modified α-GalCer analogues
Synthesis and evaluation of amino-modified α-GalCer analogues
α-GalCer analogues featuring a phytoceramide 3- and 4-amino group have been synthesized. A Mitsunobu reaction involving phthalimide was employed for the introduction of the amino groups at the 3- and 4-positions of suitable phytosphingosine-derived precursors. The influence of these modifications on the interaction with the T-cell receptor of NKT cells was investigated, as well as the capacity of the amino-modified analogues to induce a cytokine response after in vivo administration.
2928-2931
Trappeniers, Matthias
003338a8-2d89-453c-86ee-67c7464e1ac3
Chofor, René
5dcb80fd-3bf5-46ec-b31f-3b0972f400aa
Aspeslagh, Sandrine
7bfd6603-8c2a-435a-b9b9-ce5b8e071621
Li, Yali
d5937fd8-6431-43fb-8a8a-fb5143b2656f
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Zajonc, Dirk M.
47798551-44dd-4b1f-ba3d-f0b3d40f3b86
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Calenbergh, Serge Van
9a8e80de-780b-4b36-abb4-9c2b35cfd09d
June 2010
Trappeniers, Matthias
003338a8-2d89-453c-86ee-67c7464e1ac3
Chofor, René
5dcb80fd-3bf5-46ec-b31f-3b0972f400aa
Aspeslagh, Sandrine
7bfd6603-8c2a-435a-b9b9-ce5b8e071621
Li, Yali
d5937fd8-6431-43fb-8a8a-fb5143b2656f
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Zajonc, Dirk M.
47798551-44dd-4b1f-ba3d-f0b3d40f3b86
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Calenbergh, Serge Van
9a8e80de-780b-4b36-abb4-9c2b35cfd09d
Trappeniers, Matthias, Chofor, René, Aspeslagh, Sandrine, Li, Yali, Linclau, Bruno, Zajonc, Dirk M., Elewaut, Dirk and Calenbergh, Serge Van
(2010)
Synthesis and evaluation of amino-modified α-GalCer analogues.
Organic Letters, 12 (13), .
(doi:10.1021/ol100934z).
Abstract
α-GalCer analogues featuring a phytoceramide 3- and 4-amino group have been synthesized. A Mitsunobu reaction involving phthalimide was employed for the introduction of the amino groups at the 3- and 4-positions of suitable phytosphingosine-derived precursors. The influence of these modifications on the interaction with the T-cell receptor of NKT cells was investigated, as well as the capacity of the amino-modified analogues to induce a cytokine response after in vivo administration.
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Published date: June 2010
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Local EPrints ID: 170453
URI: http://eprints.soton.ac.uk/id/eprint/170453
ISSN: 1523-7060
PURE UUID: 073cbb52-db2c-476e-afe3-a25e07046d93
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Date deposited: 06 Jan 2011 16:52
Last modified: 14 Mar 2024 02:44
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Contributors
Author:
Matthias Trappeniers
Author:
René Chofor
Author:
Sandrine Aspeslagh
Author:
Yali Li
Author:
Dirk M. Zajonc
Author:
Dirk Elewaut
Author:
Serge Van Calenbergh
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