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The relationship between infant lung function and the risk of wheeze in the preschool years

Pike, K.C., Rose-Zerilli, M.J., Osvald, E. Caffrey, Inskip, H.M., Godfrey, K.M., Crozier, S.R., Roberts, G., Clough, J.B., Holloway, J.W. and Lucas, J.S. (2011) The relationship between infant lung function and the risk of wheeze in the preschool years Pediatric Pulmonology, 46, (1), pp. 75-82. (PMID:20848581).

Record type: Article


Rationale: There is evidence that perinatal lung development predicts childhood wheeze. However, very few studies have examined whether preschool wheeze is associated with lower premorbid lung function in early infancy, and as yet there is no information relating atopic and non-atopic preschool wheeze to early lung development.
Objective: To examine the association between premorbid infant lung function and preschool wheeze, and to explore associations with atopic and non-atopic wheeze phenotypes.

Methods: Infant lung function was measured in 147 healthy term infants aged 5–14 weeks. Rapid thoracoabdominal compression was performed during tidal breathing and at raised volume to measure maximal expiratory flow at functional residual capacity and forced expiratory volume in 0.4?sec (FEV0.4). Atopic status was determined by skin prick testing at 3 years and wheeze ascertained from parental questionnaires (1 and 3 years).

Measurements and Main Results: Lower early infancy was associated with wheeze in both the first and third years of life (P?=?0.002 and 0.006, respectively). Lower early infancy FEV0.4 was associated with wheeze in the first year (P?=?0.03). Compared to non-atopic children who did not wheeze, non-atopic children who wheezed in their third year of life had lower FEV0.4 (P?=?0.02), while FEV0.4 values of atopic children who wheezed were not significantly different (P?=?0.4).

Conclusions: Lower premorbid infant lung function was present in infants who subsequently wheezed during the first and third years of life. Lower FEV0.4 in early infancy was associated with non-atopic wheeze but not atopic wheeze at 3 years of age.

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Accepted/In Press date: 16 September 2010
Published date: January 2011
Keywords: wheeze, asthma, infant lung function, preschool


Local EPrints ID: 170767
ISSN: 8755-6863
PURE UUID: 312ac034-e54c-46f9-87e1-c2853feb40b5
ORCID for H.M. Inskip: ORCID iD
ORCID for K.M. Godfrey: ORCID iD
ORCID for J.W. Holloway: ORCID iD

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Date deposited: 04 Feb 2011 09:38
Last modified: 29 Aug 2017 04:35

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Author: K.C. Pike
Author: E. Caffrey Osvald
Author: H.M. Inskip ORCID iD
Author: K.M. Godfrey ORCID iD
Author: S.R. Crozier
Author: G. Roberts
Author: J.B. Clough
Author: J.W. Holloway ORCID iD
Author: J.S. Lucas

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