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Generic protease detection technology for monitoring periodontal disease

Zheng, Xinwei, Cook, Joseph P., Watkinson, Michael, Yang, Shoufeng, Douglas, Ian, Rawlinson, Andrew and Krause, Steffi (2011) Generic protease detection technology for monitoring periodontal disease Faraday Discussions, 149, pp. 37-47. (doi:10.1039/C005364C).

Record type: Article


Periodontal diseases are inflammatory conditions that affect the supporting tissues of teeth and can lead to destruction of the bone support and ultimately tooth loss if untreated. Progression of periodontitis is usually site specific but not uniform, and currently there are no accurate clinical methods for distinguishing sites where there is active disease progression from sites that are quiescent. Consequently, unnecessary and costly treatment of periodontal sites that are not progressing may occur. Three proteases have been identified as suitable markers for distinguishing sites with active disease progression and quiescent sites: human neutrophil elastase, cathepsin G and MMP8. Generic sensor materials for the detection of these three proteases have been developed based on thin dextran hydrogel films cross-linked with peptides. Degradation of the hydrogel films was monitored using impedance measurements. The target proteases were detected in the clinically relevant range within a time frame of 3 min. Good specificity for different proteases was achieved by choosing appropriate peptide cross-linkers.

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Published date: 2011
Organisations: Engineering Mats & Surface Engineerg Gp


Local EPrints ID: 172045
ISSN: 0301-7249
PURE UUID: 71438bf8-a66c-49c2-bb06-f1ca1b5b66a5

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Date deposited: 24 Jan 2011 11:20
Last modified: 18 Jul 2017 12:14

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Author: Xinwei Zheng
Author: Joseph P. Cook
Author: Michael Watkinson
Author: Shoufeng Yang
Author: Ian Douglas
Author: Andrew Rawlinson
Author: Steffi Krause

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