Mazzitelli, S., Capretto, L., Zhang, X.L., Penolazzi, L., Lambertini, E., Piva, R. and Nastruzzi, C.
Process optimization for the production of alginate microparticles containing wjmscs by a design of experiments (doe) approach
[in special issue: 11th European Sumposium on Controlled Drug Delivery]
Journal of Controlled Release, 148, (1), . (doi:10.1016/j.jconrel.2010.07.014).
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The paper describes (a) the isolation and characterization of Wharton's Jelly Mesenchymal Stem cells (WJMSCs), (b) the encapsulation of WJMSCs in alginate microbeads by an encapsulation device based on a vibrating-nozzle, (c) the optimization of the procedure for the encapsulation of WJMSCs by a Design of Experiment (DoE) approach, and (d) the evaluation of viability, proliferation and osteoblastic differentiation of the encapsulated WJMSCs.
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