Capretto, L., Focaroli, S., Zhang, X.L., Mazzitelli, S. and Nastruzzi, C.
Production of low cost microfluidic chips by a “shrinking” approach: applications to emulsion and microparticle production
Journal of Controlled Release, 148, (1), . (doi:10.1016/j.jconrel.2010.07.038).
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The present paper describes the production, using a microfluidic approach, of microparticles (constituted of cellulose acetate) and O/W emulsions (constituted of PEG-6 corn oil droplets). The general production strategy is based on the formation of water-in-oil multiphase flow by a focusing mechanism (X-junction chip). The innovative aspect of the work is represented by the fabrication procedure for the microfluidic chip production. The chips were designed and fabricated by a low cost approach using a shrinkable biocompatible polymer
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