Family friction as ?Np73 antagonises p73 and p53
Family friction as ?Np73 antagonises p73 and p53
p53 and its homolog p73 are responsible for guarding the genome and regulating cellular responses to genotoxic damage. However, life is never simple and in fact multiple isoforms of each gene exist which may have opposing functions. ?Np73 is a truncated isoform of p73 which lacks the N-terminal transactivation domain and is up-regulated in a number of diverse primary tumour types. Although its exact cellular function is unclear upregulation of ?Np73 has been linked to various pro-tumour activities. Here we review the current literature surrounding this mysterious protein and reveal its potentially important functions in tumourigenesis and treatment resistance.
?np73, p53, p73
482-486
Bailey, Sarah G.
3907c846-1c65-490a-81f1-653fea9ff7f0
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
April 2011
Bailey, Sarah G.
3907c846-1c65-490a-81f1-653fea9ff7f0
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Bailey, Sarah G., Cragg, Mark S. and Townsend, Paul A.
(2011)
Family friction as ?Np73 antagonises p73 and p53.
International Journal of Biochemistry & Cell Biology, 43 (4), .
(doi:10.1016/j.biocel.2010.12.022).
(PMID:21216303)
Abstract
p53 and its homolog p73 are responsible for guarding the genome and regulating cellular responses to genotoxic damage. However, life is never simple and in fact multiple isoforms of each gene exist which may have opposing functions. ?Np73 is a truncated isoform of p73 which lacks the N-terminal transactivation domain and is up-regulated in a number of diverse primary tumour types. Although its exact cellular function is unclear upregulation of ?Np73 has been linked to various pro-tumour activities. Here we review the current literature surrounding this mysterious protein and reveal its potentially important functions in tumourigenesis and treatment resistance.
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Accepted/In Press date: January 2011
Published date: April 2011
Keywords:
?np73, p53, p73
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Local EPrints ID: 173397
URI: http://eprints.soton.ac.uk/id/eprint/173397
ISSN: 1357-2725
PURE UUID: b87a6b5b-5e3f-4602-85a9-98087b618240
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Date deposited: 03 Feb 2011 15:24
Last modified: 14 Mar 2024 02:41
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Author:
Sarah G. Bailey
Author:
Paul A. Townsend
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