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Family friction as ?Np73 antagonises p73 and p53

Family friction as ?Np73 antagonises p73 and p53
Family friction as ?Np73 antagonises p73 and p53
p53 and its homolog p73 are responsible for guarding the genome and regulating cellular responses to genotoxic damage. However, life is never simple and in fact multiple isoforms of each gene exist which may have opposing functions. ?Np73 is a truncated isoform of p73 which lacks the N-terminal transactivation domain and is up-regulated in a number of diverse primary tumour types. Although its exact cellular function is unclear upregulation of ?Np73 has been linked to various pro-tumour activities. Here we review the current literature surrounding this mysterious protein and reveal its potentially important functions in tumourigenesis and treatment resistance.

?np73, p53, p73
1357-2725
482-486
Bailey, Sarah G.
3907c846-1c65-490a-81f1-653fea9ff7f0
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Bailey, Sarah G.
3907c846-1c65-490a-81f1-653fea9ff7f0
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db

Bailey, Sarah G., Cragg, Mark S. and Townsend, Paul A. (2011) Family friction as ?Np73 antagonises p73 and p53. International Journal of Biochemistry & Cell Biology, 43 (4), 482-486. (doi:10.1016/j.biocel.2010.12.022). (PMID:21216303)

Record type: Article

Abstract

p53 and its homolog p73 are responsible for guarding the genome and regulating cellular responses to genotoxic damage. However, life is never simple and in fact multiple isoforms of each gene exist which may have opposing functions. ?Np73 is a truncated isoform of p73 which lacks the N-terminal transactivation domain and is up-regulated in a number of diverse primary tumour types. Although its exact cellular function is unclear upregulation of ?Np73 has been linked to various pro-tumour activities. Here we review the current literature surrounding this mysterious protein and reveal its potentially important functions in tumourigenesis and treatment resistance.

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More information

Accepted/In Press date: January 2011
Published date: April 2011
Keywords: ?np73, p53, p73

Identifiers

Local EPrints ID: 173397
URI: https://eprints.soton.ac.uk/id/eprint/173397
ISSN: 1357-2725
PURE UUID: b87a6b5b-5e3f-4602-85a9-98087b618240
ORCID for Mark S. Cragg: ORCID iD orcid.org/0000-0003-2077-089X

Catalogue record

Date deposited: 03 Feb 2011 15:24
Last modified: 05 Nov 2019 01:58

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Contributors

Author: Sarah G. Bailey
Author: Mark S. Cragg ORCID iD
Author: Paul A. Townsend

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