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Chapter 78 - The placental role in fetal programming

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The principal roles of the placenta are to protect the fetus from harmful substances while actively ensuring appropriate transfer of the nutrients essential for optimal fetal growth and development. Failure of the placenta to protect or nourish the fetus can have significant consequences for the offspring both before birth and throughout its postnatal life. Poor fetal growth is associated with increased risk of many common chronic disorders in adult life, including coronary heart disease, diabetes and some forms of cancer. These long-term consequences have been referred to as “fetal programming”. The placenta is the interface between the mother and the fetus, influencing both the intrauterine environment and fetal growth, and placental function is therefore likely to be a major determinant of programming effects. Understanding the role of the placenta in fetal programming may provide new avenues for prevention and treatment of at-risk individuals.

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Citation

Lewis, Rohan M., Cleal, Jane K. and Godfrey, Keith M. (2011) Chapter 78 - The placental role in fetal programming In, Gupta, Ramesh C. (eds.) Reproductive and Developmental Toxicology. Cambridge, GB, Elsevier pp. 1039-1049. (doi:10.1016/B978-0-12-382032-7.10078-5).

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Published date: 2011

Identifiers

Local EPrints ID: 173399
URI: http://eprints.soton.ac.uk/id/eprint/173399
ISBN: 9780123820327
PURE UUID: 0bcd461b-7918-4e2d-8fd5-4a25324d80d0
ORCID for Rohan M. Lewis: ORCID iD orcid.org/0000-0003-4044-9104
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 23 Mar 2011 11:34
Last modified: 18 Jul 2017 12:13

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Contributors

Author: Rohan M. Lewis ORCID iD
Author: Jane K. Cleal
Editor: Ramesh C. Gupta

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