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The association between salt intake and adult systolic blood pressure is modified by birth weight

Perälä, Mia-Maria, Moltchanova, Elena, Kaartinen, Niina E., Mannisto, Satu, Kajantie, Eero, Osmond, Clive, Barker, D.J., Valsta, Liisa M. and Eriksson, John G. (2011) The association between salt intake and adult systolic blood pressure is modified by birth weight American Journal of Clinical Nutrition, 93, (2), pp. 422-426. (doi:10.3945/?ajcn.2010.30022). (PMID:21068355).

Record type: Article


Background: Epidemiologic evidence suggests that prenatal growth influences adult blood pressure. Nutritional factors also influence blood pressure, among them salt intake. However, it is unknown whether prenatal growth modifies the association between salt intake and blood pressure in later life.

Objective: Our aim was to examine whether the relation between salt intake and adult blood pressure is modified by birth weight.

Design: We studied 1512 participants of the Helsinki Birth Cohort Study who were born between 1934 and 1944. Information on birth weight was abstracted from birth records, and preterm births were excluded. During a clinical study, at the mean age of 62 y, blood pressure, weight, and height were measured. Diet was assessed with a validated food-frequency questionnaire. The relation between salt intake and blood pressure was tested by a piecewise multivariate regression analysis with the best fitting breakpoints to birth weight and salt intake.

Results: An inverse association was observed between birth weight and systolic blood pressure (SBP) (P = 0.02). No significant association between salt intake and SBP was observed in the whole study population. Of those whose birth weight was ?3050 g, a 1-g higher daily salt intake was associated with a 2.48-mm Hg (95% CI: 0.40, 4.52 mm Hg) higher SBP (P = 0.017) until the saturation point of 10 g. Of those whose birth weight exceeded 3050 g, SBP was not significantly associated with salt intake. For diastolic blood pressure, no significant relations were observed.

Conclusion: Adult individuals with low birth weight may be particularly sensitive to the blood pressure–raising effect of salt.

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Published date: February 2011


Local EPrints ID: 173575
ISSN: 0002-9165
PURE UUID: 676d5ef8-581c-4256-864e-bb7b7351720e
ORCID for Clive Osmond: ORCID iD

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Date deposited: 04 Feb 2011 09:46
Last modified: 18 Jul 2017 12:13

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Author: Mia-Maria Perälä
Author: Elena Moltchanova
Author: Niina E. Kaartinen
Author: Satu Mannisto
Author: Eero Kajantie
Author: Clive Osmond ORCID iD
Author: D.J. Barker
Author: Liisa M. Valsta
Author: John G. Eriksson

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