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The association between salt intake and adult systolic blood pressure is modified by birth weight

The association between salt intake and adult systolic blood pressure is modified by birth weight
The association between salt intake and adult systolic blood pressure is modified by birth weight
Background: Epidemiologic evidence suggests that prenatal growth influences adult blood pressure. Nutritional factors also influence blood pressure, among them salt intake. However, it is unknown whether prenatal growth modifies the association between salt intake and blood pressure in later life.

Objective: Our aim was to examine whether the relation between salt intake and adult blood pressure is modified by birth weight.

Design: We studied 1512 participants of the Helsinki Birth Cohort Study who were born between 1934 and 1944. Information on birth weight was abstracted from birth records, and preterm births were excluded. During a clinical study, at the mean age of 62 y, blood pressure, weight, and height were measured. Diet was assessed with a validated food-frequency questionnaire. The relation between salt intake and blood pressure was tested by a piecewise multivariate regression analysis with the best fitting breakpoints to birth weight and salt intake.

Results: An inverse association was observed between birth weight and systolic blood pressure (SBP) (P = 0.02). No significant association between salt intake and SBP was observed in the whole study population. Of those whose birth weight was ?3050 g, a 1-g higher daily salt intake was associated with a 2.48-mm Hg (95% CI: 0.40, 4.52 mm Hg) higher SBP (P = 0.017) until the saturation point of 10 g. Of those whose birth weight exceeded 3050 g, SBP was not significantly associated with salt intake. For diastolic blood pressure, no significant relations were observed.

Conclusion: Adult individuals with low birth weight may be particularly sensitive to the blood pressure–raising effect of salt.
0002-9165
422-426
Perälä, Mia-Maria
1c28423b-c2ad-46b8-a948-82e2e029ca50
Moltchanova, Elena
806dcc9e-a0e8-4b81-a090-d594e250067b
Kaartinen, Niina E.
f04253d1-937a-42fe-aff8-8405ff954d93
Mannisto, Satu
a7a2dedf-756b-4187-914d-29f3d8489106
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Valsta, Liisa M.
fc96fafc-be44-4ef2-b7cf-8123ac4ef398
Eriksson, John G.
b9eba1af-e540-4452-8f13-da6aca0651eb
Perälä, Mia-Maria
1c28423b-c2ad-46b8-a948-82e2e029ca50
Moltchanova, Elena
806dcc9e-a0e8-4b81-a090-d594e250067b
Kaartinen, Niina E.
f04253d1-937a-42fe-aff8-8405ff954d93
Mannisto, Satu
a7a2dedf-756b-4187-914d-29f3d8489106
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Valsta, Liisa M.
fc96fafc-be44-4ef2-b7cf-8123ac4ef398
Eriksson, John G.
b9eba1af-e540-4452-8f13-da6aca0651eb

Perälä, Mia-Maria, Moltchanova, Elena, Kaartinen, Niina E., Mannisto, Satu, Kajantie, Eero, Osmond, Clive, Barker, D.J., Valsta, Liisa M. and Eriksson, John G. (2011) The association between salt intake and adult systolic blood pressure is modified by birth weight. American Journal of Clinical Nutrition, 93 (2), 422-426. (doi:10.3945/?ajcn.2010.30022). (PMID:21068355)

Record type: Article

Abstract

Background: Epidemiologic evidence suggests that prenatal growth influences adult blood pressure. Nutritional factors also influence blood pressure, among them salt intake. However, it is unknown whether prenatal growth modifies the association between salt intake and blood pressure in later life.

Objective: Our aim was to examine whether the relation between salt intake and adult blood pressure is modified by birth weight.

Design: We studied 1512 participants of the Helsinki Birth Cohort Study who were born between 1934 and 1944. Information on birth weight was abstracted from birth records, and preterm births were excluded. During a clinical study, at the mean age of 62 y, blood pressure, weight, and height were measured. Diet was assessed with a validated food-frequency questionnaire. The relation between salt intake and blood pressure was tested by a piecewise multivariate regression analysis with the best fitting breakpoints to birth weight and salt intake.

Results: An inverse association was observed between birth weight and systolic blood pressure (SBP) (P = 0.02). No significant association between salt intake and SBP was observed in the whole study population. Of those whose birth weight was ?3050 g, a 1-g higher daily salt intake was associated with a 2.48-mm Hg (95% CI: 0.40, 4.52 mm Hg) higher SBP (P = 0.017) until the saturation point of 10 g. Of those whose birth weight exceeded 3050 g, SBP was not significantly associated with salt intake. For diastolic blood pressure, no significant relations were observed.

Conclusion: Adult individuals with low birth weight may be particularly sensitive to the blood pressure–raising effect of salt.

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Published date: February 2011

Identifiers

Local EPrints ID: 173575
URI: http://eprints.soton.ac.uk/id/eprint/173575
ISSN: 0002-9165
PURE UUID: 676d5ef8-581c-4256-864e-bb7b7351720e
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 04 Feb 2011 09:46
Last modified: 14 Mar 2024 02:38

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Contributors

Author: Mia-Maria Perälä
Author: Elena Moltchanova
Author: Niina E. Kaartinen
Author: Satu Mannisto
Author: Eero Kajantie
Author: Clive Osmond ORCID iD
Author: D.J. Barker
Author: Liisa M. Valsta
Author: John G. Eriksson

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