Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: A systematic review
Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: A systematic review
PURPOSE: The aim of this systematic review was to summarize and evaluate the evidence available for oral supplementation with coenzyme Q10 (CoQ10) to improve the tolerability of cancer treatments.
MATERIALS AND METHODS: Searches for all published and unpublished controlled trials were carried out on seven databases. Manufacturers of CoQ10 were identified and contacted. Controlled clinical trials of monopreparations of CoQ10 administered orally to cancer patients were included. No language restrictions were imposed. Data were extracted independently by two authors according to predefined criteria.
RESULTS: Six studies were included in the review, including three randomized clinical trials and three nonrandomized clinical trials. Patients in five of six studies received anthracyclines. The results suggested that CoQ10 provides some protection against cardiotoxicity or liver toxicity during cancer treatment. However, because of inadequate reporting and analysis, as well as questionable validity of outcome measures, the results are not conclusive.
CONCLUSION: Suggestions that CoQ10 might reduce the toxicity of cancer treatments have not been tested by rigorous trials. Further investigations are necessary to determine whether CoQ10 can improve the tolerability of cancer treatments.
systematic review, cancer treatments, tolerability, coenzyme Q10, efficacy
4418-4424
Roffe, L.
cc330de8-dfcb-4e8f-bcdc-34f48c50eaa5
Schmidt, K.
34857dc9-1578-4852-8acc-f11b639fda84
Ernst, E.
3978447d-2318-4c4f-81bd-84fa8e25dbdc
November 2004
Roffe, L.
cc330de8-dfcb-4e8f-bcdc-34f48c50eaa5
Schmidt, K.
34857dc9-1578-4852-8acc-f11b639fda84
Ernst, E.
3978447d-2318-4c4f-81bd-84fa8e25dbdc
Roffe, L., Schmidt, K. and Ernst, E.
(2004)
Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: A systematic review.
Journal of Clinical Oncology, 22 (21), .
(doi:10.1200/JCO.2004.02.034).
Abstract
PURPOSE: The aim of this systematic review was to summarize and evaluate the evidence available for oral supplementation with coenzyme Q10 (CoQ10) to improve the tolerability of cancer treatments.
MATERIALS AND METHODS: Searches for all published and unpublished controlled trials were carried out on seven databases. Manufacturers of CoQ10 were identified and contacted. Controlled clinical trials of monopreparations of CoQ10 administered orally to cancer patients were included. No language restrictions were imposed. Data were extracted independently by two authors according to predefined criteria.
RESULTS: Six studies were included in the review, including three randomized clinical trials and three nonrandomized clinical trials. Patients in five of six studies received anthracyclines. The results suggested that CoQ10 provides some protection against cardiotoxicity or liver toxicity during cancer treatment. However, because of inadequate reporting and analysis, as well as questionable validity of outcome measures, the results are not conclusive.
CONCLUSION: Suggestions that CoQ10 might reduce the toxicity of cancer treatments have not been tested by rigorous trials. Further investigations are necessary to determine whether CoQ10 can improve the tolerability of cancer treatments.
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Published date: November 2004
Additional Information:
Supported by a grant from the British Medical Association (L.R.) and the Pilkington Family Trusts (K.S.).
Keywords:
systematic review, cancer treatments, tolerability, coenzyme Q10, efficacy
Identifiers
Local EPrints ID: 17386
URI: http://eprints.soton.ac.uk/id/eprint/17386
ISSN: 1527-7755
PURE UUID: 1d733b38-fc7b-4f15-beb9-7c12595f84f6
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Date deposited: 02 Sep 2005
Last modified: 15 Mar 2024 05:58
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Author:
L. Roffe
Author:
K. Schmidt
Author:
E. Ernst
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