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Developmental origins of the metabolic syndrome: body clocks and stress responses

Developmental origins of the metabolic syndrome: body clocks and stress responses
Developmental origins of the metabolic syndrome: body clocks and stress responses
The prevalence of the metabolic syndrome, which represents a spectrum of metabolic and cardiovascular disorders, continues to increase at an alarming rate in contemporary society. Inadequate responses of an individual to environmental challenges such as unbalanced diet or lack of physical exercise during their life course has been recognised to increase risk of this pathological condition. Recent evidence suggests that this may involve alterations in the settings of the circadian clock system, which consists of oscillating molecular pacemakers found not only in the hypothalamic region of the brain but also in most peripheral tissues, and of the hypothalamic–pituitary–adrenal (HPA) axis which regulates stress responses. These two systems are now known to interact to produce an integrated response to environmental challenges. In this review, we highlight the importance of environmental cues during early development in establishing the homeostatic set-points of the circadian clock and HPA stress systems. These effects can operate within the normal range and are not in themselves pathological, but can nevertheless affect an individual’s response to environmental challenges in adult life and thus their risk of the metabolic syndrome.

metabolic syndrome, circadian rhythm, hypothalamic–pituitary–adrenal axis nutrition, developmental origins of health and disease, Stress response, body clocks
0889-1591
214-220
Cagampang, F.
7cf57d52-4a65-4554-8306-ed65226bc50e
Poore, K.R.
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Cagampang, F.
7cf57d52-4a65-4554-8306-ed65226bc50e
Poore, K.R.
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Cagampang, F., Poore, K.R. and Hanson, Mark A. (2011) Developmental origins of the metabolic syndrome: body clocks and stress responses. Brain, Behavior and Immunity, 25 (2), 214-220. (doi:10.1016/j.bbi.2010.09.005). (PMID:20851177)

Record type: Article

Abstract

The prevalence of the metabolic syndrome, which represents a spectrum of metabolic and cardiovascular disorders, continues to increase at an alarming rate in contemporary society. Inadequate responses of an individual to environmental challenges such as unbalanced diet or lack of physical exercise during their life course has been recognised to increase risk of this pathological condition. Recent evidence suggests that this may involve alterations in the settings of the circadian clock system, which consists of oscillating molecular pacemakers found not only in the hypothalamic region of the brain but also in most peripheral tissues, and of the hypothalamic–pituitary–adrenal (HPA) axis which regulates stress responses. These two systems are now known to interact to produce an integrated response to environmental challenges. In this review, we highlight the importance of environmental cues during early development in establishing the homeostatic set-points of the circadian clock and HPA stress systems. These effects can operate within the normal range and are not in themselves pathological, but can nevertheless affect an individual’s response to environmental challenges in adult life and thus their risk of the metabolic syndrome.

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More information

Published date: February 2011
Keywords: metabolic syndrome, circadian rhythm, hypothalamic–pituitary–adrenal axis nutrition, developmental origins of health and disease, Stress response, body clocks
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 174971
URI: https://eprints.soton.ac.uk/id/eprint/174971
ISSN: 0889-1591
PURE UUID: 4619e29c-91cb-48ed-b5d7-8314d0f62a10
ORCID for F. Cagampang: ORCID iD orcid.org/0000-0003-4404-9853
ORCID for K.R. Poore: ORCID iD orcid.org/0000-0002-1455-0615
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

Catalogue record

Date deposited: 18 Feb 2011 14:45
Last modified: 11 Dec 2018 01:35

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