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Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis

Record type: Article

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is accompanied by the emergence of autoreactive T cells and a reduction in regulatory T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted NK T cells, suggesting a role for these cells in the regulation of SLE. In this study, we show that CD1d deficiency exacerbates lupus nephritis induced by the hydrocarbon oil pristane. This exacerbation in disease is associated with: 1) reduced TNF-? and IL-4 production by T cells, especially during the disease induction phase; and 2) expansion of marginal zone B cells. Strikingly, inoculation of pristane in wild-type mice resulted in reduced numbers and/or functions of NK T cells and CD1d-expressing dendritic cells. These findings suggest that CD1d may play an immunoregulatory role in the development of lupus in the pristane-induced model.

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Citation

Yang, Jun-Qi, Singh, Avneesh K., Wilson, Michael T., Satoh, Minoru, Stanic, Aleksandar K., Park, Jang-June, Hong, Seokmann, Gadola, Stephan D., Mizutani, Akiel, Kakumanu, Srinvasa R., Reeves, Westly H., Cerundolo, Vincenzo, Joyce, Sebastian, Van Kaer, Luc and Singh, Ram Raj (2003) Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis Journal of Immunology, 171, (4), pp. 2142-2153. (PMID:1290252).

More information

Published date: 15 August 2003

Identifiers

Local EPrints ID: 175419
URI: http://eprints.soton.ac.uk/id/eprint/175419
ISSN: 0022-1767
PURE UUID: bcd3bb4d-08a6-4cce-b831-d7be0b9bf56d

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Date deposited: 23 Feb 2011 13:49
Last modified: 18 Jul 2017 12:09

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Contributors

Author: Jun-Qi Yang
Author: Avneesh K. Singh
Author: Michael T. Wilson
Author: Minoru Satoh
Author: Aleksandar K. Stanic
Author: Jang-June Park
Author: Seokmann Hong
Author: Stephan D. Gadola
Author: Akiel Mizutani
Author: Srinvasa R. Kakumanu
Author: Westly H. Reeves
Author: Vincenzo Cerundolo
Author: Sebastian Joyce
Author: Luc Van Kaer
Author: Ram Raj Singh

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