Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection
Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection
Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, V24/Vß11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike V24/Vß11 NKT cells found in blood, those in the liver appeared to be recently activated.
2251-2257
Lucas, Michaela
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Gadola, Stephan
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Meier, Ute
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Young, Neil T.
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Harcourt, Gillian
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Karadimitris, Anastasios
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Coumi, Nikki
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Brown, Dave
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Dusheiko, Geoff
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Cerundolo, Vincenzo
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Klenerman, Paul
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February 2003
Lucas, Michaela
1b24eb3d-f057-405b-9603-ff5856ec50c9
Gadola, Stephan
ef2fa6cf-2ccc-4fea-a7a5-cc03a9d13ab1
Meier, Ute
4ed15d12-a634-4e9a-9ef1-b287e4f6ec34
Young, Neil T.
420c5bc3-494e-4840-9af2-dc1b081291b1
Harcourt, Gillian
16061b2b-13a0-4020-ac17-e42f32346182
Karadimitris, Anastasios
ed4cf62f-ca4f-444c-8145-d58367707da1
Coumi, Nikki
045cbff2-25ab-4c89-b86f-9f5576a1290b
Brown, Dave
897ef8ae-e86d-4084-8558-ae60d845fa0a
Dusheiko, Geoff
e29a38e2-7d7d-4f7f-bc79-7f37745790d3
Cerundolo, Vincenzo
813bcd4a-ca19-48a3-86e4-71d131e2065a
Klenerman, Paul
aa4c00a6-1a4d-4a4f-ac21-2131996344a7
Lucas, Michaela, Gadola, Stephan, Meier, Ute, Young, Neil T., Harcourt, Gillian, Karadimitris, Anastasios, Coumi, Nikki, Brown, Dave, Dusheiko, Geoff, Cerundolo, Vincenzo and Klenerman, Paul
(2003)
Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection.
Journal of Virology, 77 (3), .
(doi:10.1128/JVI.77.3.2251-2257.2003).
(PMID:12525661)
Abstract
Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, V24/Vß11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike V24/Vß11 NKT cells found in blood, those in the liver appeared to be recently activated.
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Published date: February 2003
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Local EPrints ID: 175435
URI: http://eprints.soton.ac.uk/id/eprint/175435
ISSN: 0022-538X
PURE UUID: 0d06c90b-c6bf-4393-82ec-7be02f06e1c2
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Date deposited: 23 Feb 2011 14:25
Last modified: 14 Mar 2024 02:36
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Contributors
Author:
Michaela Lucas
Author:
Stephan Gadola
Author:
Ute Meier
Author:
Neil T. Young
Author:
Gillian Harcourt
Author:
Anastasios Karadimitris
Author:
Nikki Coumi
Author:
Dave Brown
Author:
Geoff Dusheiko
Author:
Vincenzo Cerundolo
Author:
Paul Klenerman
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