Lucas, Michaela, Gadola, Stephan, Meier, Ute, Young, Neil T., Harcourt, Gillian, Karadimitris, Anastasios, Coumi, Nikki, Brown, Dave, Dusheiko, Geoff, Cerundolo, Vincenzo and Klenerman, Paul
Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection
Journal of Virology, 77, (3), . (doi:10.1128/JVI.77.3.2251-2257.2003). (PMID:12525661).
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Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, V24/Vß11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike V24/Vß11 NKT cells found in blood, those in the liver appeared to be recently activated.
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