Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest base camp


Holloway, Cameron J., Montgomery, Hugh E., Murray, Andrew J., Cochlin, Lowri E., Codreanu, Ion, Hopwood, Naomi, Johnson, Andrew W., Rider, Oliver J., Levett, Denny Z.H., Tyler, Damian J., Francis, Jane M., Neubauer, Stefan, Grocott, Michael P.W. and Clarke, Kieran (2011) Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest base camp FASEB Journal, 25, (2), pp. 792-796. (doi:10.1096/fj.10-172999). (PMID:20978235).

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Description/Abstract

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diately after returning from Mt. Everest, total body weight had fallen by 3% (P<
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ed for changes in body surface area, had disproportionately decreased by 11% (P<
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duction in peak left ventricular filling rates and mitral inflow E/A, by 17% (P<
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eft ventricular filling rates and mitral inflow E/A, by 17% (P<0.05) and 24% (P<
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on status. Compared with pretrek, cardiac PCr/ATP ratio had decreased by 18% (P<
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Item Type: Article
Digital Object Identifier (DOI): doi:10.1096/fj.10-172999
ISSNs: 0892-6638 (print)
Keywords: cardiac function, cardiac energy metabolism
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RB Pathology
Organisations: Clinical & Experimental Sciences
ePrint ID: 175451
Date :
Date Event
February 2011Published
Date Deposited: 08 Mar 2011 10:58
Last Modified: 21 Feb 2017 05:58
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/175451

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