Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2
Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2
We have identified an HLA-A2-restricted CD8+ T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.
2757-2761
Lautscham, Georg
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Haigh, Tracey
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Mayrhofer, Sabine
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Taylor, Graham
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Croom-Carter, Debbie
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Leese, Alison
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Gadola, Stephan
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Cerundolo, Vincenzo
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Rickinson, Alan
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Blake, Neil
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February 2003
Lautscham, Georg
97ad603c-36b0-496d-8a0e-1e52b1516aee
Haigh, Tracey
4f2ed64d-18f6-4bb4-956d-c8d150a6d5ea
Mayrhofer, Sabine
a51ec7f0-a869-45db-a202-bf628d48a685
Taylor, Graham
0af050d3-96b1-44c9-92ae-ce50b4393e64
Croom-Carter, Debbie
750fcf65-b54d-4b18-bc0d-ea2ab3e62a6a
Leese, Alison
916e00f9-f42e-45c5-8b90-b236e652f42d
Gadola, Stephan
ef2fa6cf-2ccc-4fea-a7a5-cc03a9d13ab1
Cerundolo, Vincenzo
813bcd4a-ca19-48a3-86e4-71d131e2065a
Rickinson, Alan
db05c1c3-b821-4894-8e8f-313f9b84ebe0
Blake, Neil
5a18e7b9-8bcc-41be-b447-95d915fc0dfd
Lautscham, Georg, Haigh, Tracey, Mayrhofer, Sabine, Taylor, Graham, Croom-Carter, Debbie, Leese, Alison, Gadola, Stephan, Cerundolo, Vincenzo, Rickinson, Alan and Blake, Neil
(2003)
Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2.
Journal of Virology, 77 (4), .
(doi:10.1128/JVI.77.4.2757-2761.2003).
(PMID:12552018)
Abstract
We have identified an HLA-A2-restricted CD8+ T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.
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Published date: February 2003
Identifiers
Local EPrints ID: 175469
URI: http://eprints.soton.ac.uk/id/eprint/175469
ISSN: 0022-538X
PURE UUID: ef56bbcf-4cdd-43fc-8f78-9bd9ea4a0af1
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Date deposited: 23 Feb 2011 15:25
Last modified: 14 Mar 2024 02:37
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Contributors
Author:
Georg Lautscham
Author:
Tracey Haigh
Author:
Sabine Mayrhofer
Author:
Graham Taylor
Author:
Debbie Croom-Carter
Author:
Alison Leese
Author:
Stephan Gadola
Author:
Vincenzo Cerundolo
Author:
Alan Rickinson
Author:
Neil Blake
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