Allelic association in the FRAX region
Allelic association in the FRAX region
The sex chromosomes enable direct determination of haplotypes, and the analysis of 8 microsatellite markers from the FRAX region on Xq27-q28 contributes 7219 independent haplotypes from our study in Wessex. Allelic association increases with frequency of alleles, and is less for trinucleotide than dinucleotide repeats. The estimate of ?, the exponential decline of association with distance in kb, is 0.0023. The swept radius 1/? estimates the distance at which disequilibrium falls to e?1? .37 of its initial value. The current study estimates the swept radius of association to be 433 kb, which is surprisingly close to estimates for SNPs, and suggests that a marker density of 1/100 kb should be powerful in regions such as FRAX. An explanation for these results is offered, and some speculations made about what will be found when SNPs are subjected to an equally intensive study in multiple regions.
513-518
Ennis, S.
7b57f188-9d91-4beb-b217-09856146f1e9
Collins, A.
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Murray, A.
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MacPherson, J.N.
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Morton, N.E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
November 2000
Ennis, S.
7b57f188-9d91-4beb-b217-09856146f1e9
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Murray, A.
d80b2bea-5bde-448f-a1d2-c5627db1df99
MacPherson, J.N.
ef609e90-d688-4129-894c-f841ab3f2c29
Morton, N.E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Ennis, S., Collins, A., Murray, A., MacPherson, J.N. and Morton, N.E.
(2000)
Allelic association in the FRAX region.
Annals of Human Genetics, 64 (6), .
(doi:10.1046/j.1469-1809.2000.6460513.x).
(PMID:11281215)
Abstract
The sex chromosomes enable direct determination of haplotypes, and the analysis of 8 microsatellite markers from the FRAX region on Xq27-q28 contributes 7219 independent haplotypes from our study in Wessex. Allelic association increases with frequency of alleles, and is less for trinucleotide than dinucleotide repeats. The estimate of ?, the exponential decline of association with distance in kb, is 0.0023. The swept radius 1/? estimates the distance at which disequilibrium falls to e?1? .37 of its initial value. The current study estimates the swept radius of association to be 433 kb, which is surprisingly close to estimates for SNPs, and suggests that a marker density of 1/100 kb should be powerful in regions such as FRAX. An explanation for these results is offered, and some speculations made about what will be found when SNPs are subjected to an equally intensive study in multiple regions.
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Published date: November 2000
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Local EPrints ID: 175741
URI: http://eprints.soton.ac.uk/id/eprint/175741
ISSN: 0003-4800
PURE UUID: 1e054d12-f627-4fd9-8ac8-c253d2b691f1
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Date deposited: 28 Feb 2011 10:06
Last modified: 15 Mar 2024 02:43
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Author:
A. Murray
Author:
J.N. MacPherson
Author:
N.E. Morton
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