The University of Southampton
University of Southampton Institutional Repository

Allelic association in the FRAX region

Allelic association in the FRAX region
Allelic association in the FRAX region
The sex chromosomes enable direct determination of haplotypes, and the analysis of 8 microsatellite markers from the FRAX region on Xq27-q28 contributes 7219 independent haplotypes from our study in Wessex. Allelic association increases with frequency of alleles, and is less for trinucleotide than dinucleotide repeats. The estimate of ?, the exponential decline of association with distance in kb, is 0.0023. The swept radius 1/? estimates the distance at which disequilibrium falls to e?1? .37 of its initial value. The current study estimates the swept radius of association to be 433 kb, which is surprisingly close to estimates for SNPs, and suggests that a marker density of 1/100 kb should be powerful in regions such as FRAX. An explanation for these results is offered, and some speculations made about what will be found when SNPs are subjected to an equally intensive study in multiple regions.

0003-4800
513-518
Ennis, S.
7b57f188-9d91-4beb-b217-09856146f1e9
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Murray, A.
d80b2bea-5bde-448f-a1d2-c5627db1df99
MacPherson, J.N.
ef609e90-d688-4129-894c-f841ab3f2c29
Morton, N.E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Ennis, S.
7b57f188-9d91-4beb-b217-09856146f1e9
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Murray, A.
d80b2bea-5bde-448f-a1d2-c5627db1df99
MacPherson, J.N.
ef609e90-d688-4129-894c-f841ab3f2c29
Morton, N.E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7

Ennis, S., Collins, A., Murray, A., MacPherson, J.N. and Morton, N.E. (2000) Allelic association in the FRAX region. Annals of Human Genetics, 64 (6), 513-518. (doi:10.1046/j.1469-1809.2000.6460513.x). (PMID:11281215)

Record type: Article

Abstract

The sex chromosomes enable direct determination of haplotypes, and the analysis of 8 microsatellite markers from the FRAX region on Xq27-q28 contributes 7219 independent haplotypes from our study in Wessex. Allelic association increases with frequency of alleles, and is less for trinucleotide than dinucleotide repeats. The estimate of ?, the exponential decline of association with distance in kb, is 0.0023. The swept radius 1/? estimates the distance at which disequilibrium falls to e?1? .37 of its initial value. The current study estimates the swept radius of association to be 433 kb, which is surprisingly close to estimates for SNPs, and suggests that a marker density of 1/100 kb should be powerful in regions such as FRAX. An explanation for these results is offered, and some speculations made about what will be found when SNPs are subjected to an equally intensive study in multiple regions.

Full text not available from this repository.

More information

Published date: November 2000

Identifiers

Local EPrints ID: 175741
URI: https://eprints.soton.ac.uk/id/eprint/175741
ISSN: 0003-4800
PURE UUID: 1e054d12-f627-4fd9-8ac8-c253d2b691f1
ORCID for S. Ennis: ORCID iD orcid.org/0000-0003-2648-0869
ORCID for A. Collins: ORCID iD orcid.org/0000-0001-7108-0771

Catalogue record

Date deposited: 28 Feb 2011 10:06
Last modified: 31 Jan 2019 01:37

Export record

Altmetrics

Contributors

Author: S. Ennis ORCID iD
Author: A. Collins ORCID iD
Author: A. Murray
Author: J.N. MacPherson
Author: N.E. Morton

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×