Childhood body mass index and adult pro-inflammatory and pro-thrombotic risk factors: data from the New Dehli birth cohort

Lakshmy, Ramakrishnan, Fall, Caroline H.D., Sachdev, Harshpal Singh, Osmond, Clive, Prabhakaran, Dorairaj, Biswas, Sushant Dey, Tandon, Nikhil, Ramji, Siddharth, Reddy, Kolli Srinath, Barker, David J.P. and Bhargava, Santosh K. (2011) Childhood body mass index and adult pro-inflammatory and pro-thrombotic risk factors: data from the New Dehli birth cohort. International Journal of Epidemiology, 40 (1), 102-111. (doi:10.1093/ije/dyq121). (PMID:20660641)

Abstract

Objective: Weight gain and growth in early life may influence adult pro-inflammatory and pro-thrombotic cardiovascular risk factors.

Methods: Follow-up of a birth cohort in New Delhi, India, whose weight and height were measured every 6 months until age 21 years. Body mass index (BMI) at birth, during infancy (2 years), childhood (11 years) and adulthood (26–32 years) and BMI gain between these ages were analysed in 886 men and 640 women with respect to adult fibrinogen, high-sensitivity C-reactive protein (hsCRP) and plasminogen activator inhibitor-1 (PAI-1) concentrations.

Results: All the pro-inflammatory/pro-thrombotic risk factors were higher in participants with higher adiposity. In women, BMI at birth and age 2 years was inversely related to fibrinogen (P?=?0.002 and 0.05) and, after adjusting for adult adiposity, to hsCRP (P?=?0.02 and 0.009). After adjusting for adult adiposity, BMI at 2 years was inversely related to hsCRP and PAI-1 concentrations (P?<?0.001 and 0.02) in men. BMI gain between 2 and 11 years and/or 11 years to adulthood was positively associated with fibrinogen and hsCRP in women and with hsCRP and PAI-1 in men.

Conclusions: Thinness at birth or during infancy, and accelerated BMI gain during childhood/adolescence are associated with a pro-inflammatory/pro-thrombotic state in adult life. An altered inflammatory state could be one link between small newborn/infant size and adult cardiovascular disease. Associations between pro-inflammatory markers and childhood/adolescent BMI gain are probably mediated through adult adiposity.

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Contributors

Author: Caroline H.D. Fall

Author: Clive Osmond

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