In vivo glucose monitoring: the clinical reality and the promise
In vivo glucose monitoring: the clinical reality and the promise
Glucose monitoring is an essential component of modern diabetes management. Three in vivo glucose sensors are now available for clinical use: a subcutaneously implanted amperometric enzyme electrode, a reverse iontophoresis system and a microdialysis-based device. Improvements in glucose-sensing technology continue to be sought, e.g. wired enzyme technology, viscometric affinity sensing and totally implanted glucose sensors. Non-invasive glucose sensing is the ultimate goal of glucose monitoring, but the most investigated approach, near-infrared (NIR) spectroscopy, is presently too imprecise for clinical application. Fluorescence-based glucose sensing offers several advantages and we are investigating strategies which include NIR-based fluorescence resonance energy transfer using concanavalin A/dextran; changes in the intrinsic fluorescence of hexokinase encapsulated in sol-gel; and non-invasive glucose monitoring of cells by measuring glucose-related changes in NADP(H).
diabetes, glucose biosensor, glucose monitoring, enzyme electrode, fluorescence, non-invasive monitoring
1897-1902
Pickup, John C
892f5d10-51c8-41f3-a92f-cff21816459a
Hussain, Faeiza
05d57336-bc5f-4798-8aa2-2bdc24d2d2a5
Evans, Nicholas D
06a05c97-bfed-4abb-9244-34ec9f4b4b95
Sachedina, Nabihah
a543340f-135b-4230-b737-b5279744914b
15 April 2005
Pickup, John C
892f5d10-51c8-41f3-a92f-cff21816459a
Hussain, Faeiza
05d57336-bc5f-4798-8aa2-2bdc24d2d2a5
Evans, Nicholas D
06a05c97-bfed-4abb-9244-34ec9f4b4b95
Sachedina, Nabihah
a543340f-135b-4230-b737-b5279744914b
Pickup, John C, Hussain, Faeiza, Evans, Nicholas D and Sachedina, Nabihah
(2005)
In vivo glucose monitoring: the clinical reality and the promise.
Biosensors & Bioelectronics, 20 (10), .
(doi:10.1016/j.bios.2004.08.016).
(PMID:15741056)
Abstract
Glucose monitoring is an essential component of modern diabetes management. Three in vivo glucose sensors are now available for clinical use: a subcutaneously implanted amperometric enzyme electrode, a reverse iontophoresis system and a microdialysis-based device. Improvements in glucose-sensing technology continue to be sought, e.g. wired enzyme technology, viscometric affinity sensing and totally implanted glucose sensors. Non-invasive glucose sensing is the ultimate goal of glucose monitoring, but the most investigated approach, near-infrared (NIR) spectroscopy, is presently too imprecise for clinical application. Fluorescence-based glucose sensing offers several advantages and we are investigating strategies which include NIR-based fluorescence resonance energy transfer using concanavalin A/dextran; changes in the intrinsic fluorescence of hexokinase encapsulated in sol-gel; and non-invasive glucose monitoring of cells by measuring glucose-related changes in NADP(H).
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Published date: 15 April 2005
Keywords:
diabetes, glucose biosensor, glucose monitoring, enzyme electrode, fluorescence, non-invasive monitoring
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Local EPrints ID: 176167
URI: http://eprints.soton.ac.uk/id/eprint/176167
ISSN: 0956-5663
PURE UUID: 078fdec4-e644-4b13-9134-8e7ebba247c5
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Date deposited: 08 Mar 2011 11:59
Last modified: 14 Mar 2024 02:56
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Author:
John C Pickup
Author:
Faeiza Hussain
Author:
Nabihah Sachedina
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