Complexity in biomaterials for tissue engineering
Complexity in biomaterials for tissue engineering
The molecular and physical information coded within the extracellular milieu is informing the development of a new generation of biomaterials for tissue engineering. Several powerful extracellular influences have already found their way into cell-instructive scaffolds, while others remain largely unexplored. Yet for commercial success tissue engineering products must be not only efficacious but also cost-effective, introducing a potential dichotomy between the need for sophistication and ease of production. This is spurring interest in recreating extracellular influences in simplified forms, from the reduction of biopolymers into short functional domains, to the use of basic chemistries to manipulate cell fate. In the future these exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering.
457-70
Place, Elsie S.
3e8ba5fe-aa83-4cdc-8fb8-3e41e1295427
Evans, Nicholas D.
06a05c97-bfed-4abb-9244-34ec9f4b4b95
Stevens, Molly M.
f0c6dded-e31c-4e40-bfc4-2a70fad118a6
June 2009
Place, Elsie S.
3e8ba5fe-aa83-4cdc-8fb8-3e41e1295427
Evans, Nicholas D.
06a05c97-bfed-4abb-9244-34ec9f4b4b95
Stevens, Molly M.
f0c6dded-e31c-4e40-bfc4-2a70fad118a6
Place, Elsie S., Evans, Nicholas D. and Stevens, Molly M.
(2009)
Complexity in biomaterials for tissue engineering.
Nature Materials, 8 (6), .
(doi:10.1038/nmat2441).
(PMID:19458646)
Abstract
The molecular and physical information coded within the extracellular milieu is informing the development of a new generation of biomaterials for tissue engineering. Several powerful extracellular influences have already found their way into cell-instructive scaffolds, while others remain largely unexplored. Yet for commercial success tissue engineering products must be not only efficacious but also cost-effective, introducing a potential dichotomy between the need for sophistication and ease of production. This is spurring interest in recreating extracellular influences in simplified forms, from the reduction of biopolymers into short functional domains, to the use of basic chemistries to manipulate cell fate. In the future these exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering.
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Published date: June 2009
Organisations:
Dev Origins of Health & Disease, Bioengineering Sciences
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Local EPrints ID: 176173
URI: http://eprints.soton.ac.uk/id/eprint/176173
ISSN: 1476-1122
PURE UUID: 17956f4f-8818-41fa-a6e4-86cf4d659bc0
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Date deposited: 04 Mar 2011 10:33
Last modified: 14 Mar 2024 02:56
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Author:
Elsie S. Place
Author:
Molly M. Stevens
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