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Phosphoinositide 3-kinases and regulation of embryonic stem cell fate

Phosphoinositide 3-kinases and regulation of embryonic stem cell fate
Phosphoinositide 3-kinases and regulation of embryonic stem cell fate
ES (embryonic stem) cell lines are derived from the epiblast of pre-implantation embryos and like the inner cell mass cells from which they are derived exhibit the remarkable property of pluripotency, namely the ability to differentiate into all cell lineages comprising the adult organism. ES cells and their differentiated progeny offer tremendous potential to regenerative medicine, particularly as cellular therapies for the treatment of a wide variety of chronic disorders, such as Type 1 diabetes, Parkinson's disease and retinal degeneration. In order for this potential to be realized, a detailed understanding of the molecular mechanisms regulating the fundamental properties of ES cells, i.e. pluripotency, proliferation and differentiation, is required. In the present paper, we review the evidence that PI3K (phosphoinositide 3-kinase)-dependent signalling plays a role in regulation of both ES cell pluripotency and proliferation.
bone morphogenetic protein (bmp), embryonic stem cell (es cell), phosphoinositide 3-kinase (pi3k), pluripotency, self-renewal
0300-5127
225-228
Welham, M.J.
ff1f42a8-deb3-4b1c-bde1-d424837627c7
Storm, M.P.
badfa32a-ad63-4870-b772-0df362612bbb
Kingham, E.
cfae2c9c-ad37-471f-91d9-7affc66cb943
Bone, H.K.
790fb69c-1bd5-443a-8f02-54105cdd0bf7
Welham, M.J.
ff1f42a8-deb3-4b1c-bde1-d424837627c7
Storm, M.P.
badfa32a-ad63-4870-b772-0df362612bbb
Kingham, E.
cfae2c9c-ad37-471f-91d9-7affc66cb943
Bone, H.K.
790fb69c-1bd5-443a-8f02-54105cdd0bf7

Welham, M.J., Storm, M.P., Kingham, E. and Bone, H.K. (2007) Phosphoinositide 3-kinases and regulation of embryonic stem cell fate. Biochemical Society Transactions, 35 (2), 225-228. (PMID:17371244)

Record type: Article

Abstract

ES (embryonic stem) cell lines are derived from the epiblast of pre-implantation embryos and like the inner cell mass cells from which they are derived exhibit the remarkable property of pluripotency, namely the ability to differentiate into all cell lineages comprising the adult organism. ES cells and their differentiated progeny offer tremendous potential to regenerative medicine, particularly as cellular therapies for the treatment of a wide variety of chronic disorders, such as Type 1 diabetes, Parkinson's disease and retinal degeneration. In order for this potential to be realized, a detailed understanding of the molecular mechanisms regulating the fundamental properties of ES cells, i.e. pluripotency, proliferation and differentiation, is required. In the present paper, we review the evidence that PI3K (phosphoinositide 3-kinase)-dependent signalling plays a role in regulation of both ES cell pluripotency and proliferation.

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More information

Published date: April 2007
Keywords: bone morphogenetic protein (bmp), embryonic stem cell (es cell), phosphoinositide 3-kinase (pi3k), pluripotency, self-renewal

Identifiers

Local EPrints ID: 176441
URI: http://eprints.soton.ac.uk/id/eprint/176441
ISSN: 0300-5127
PURE UUID: e51b873c-ba04-4103-abed-bf383012e212

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Date deposited: 07 Mar 2011 16:43
Last modified: 08 Nov 2021 18:59

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Contributors

Author: M.J. Welham
Author: M.P. Storm
Author: E. Kingham
Author: H.K. Bone

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