DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology
DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology
Oligonucleotides have recently gained increased attraction as a supramolecular scaffold for the design and synthesis of functional molecules on the nanometre scale. This tutorial review focuses on the recent progress in this highly active field of research with an emphasis on covalent modifications of DNA; non-covalent interactions of DNA with molecules such as groove binders or intercalators are not part of this review. Both terminal and internal modifications are covered, and the various points of attachment (nucleobase, sugar moiety or phosphodiester backbone) are compared. Using selected examples of the recent literature, the diversity of the functionalities that have been incorporated into DNA strands is discussed.
138-148
Bandy, Thomas J.
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Brewer, Ashley
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Burns, Jonathan R.
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Marth, Gabriella
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Nguyen, ThaoNguyen
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Stulz, Eugen
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2011
Bandy, Thomas J.
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Brewer, Ashley
d10b9ab3-b920-498b-8a3c-b4b5d16106e5
Burns, Jonathan R.
648a50f5-bcca-4989-8de3-60cc582b7ed9
Marth, Gabriella
515790e1-1d78-4827-9cae-76947292903b
Nguyen, ThaoNguyen
dfe06677-7b72-4616-a409-4b8ada09c5f4
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
Bandy, Thomas J., Brewer, Ashley, Burns, Jonathan R., Marth, Gabriella, Nguyen, ThaoNguyen and Stulz, Eugen
(2011)
DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology.
Chemical Society Reviews, 40 (1), .
(doi:10.1039/b820255a).
(PMID:20694258)
Abstract
Oligonucleotides have recently gained increased attraction as a supramolecular scaffold for the design and synthesis of functional molecules on the nanometre scale. This tutorial review focuses on the recent progress in this highly active field of research with an emphasis on covalent modifications of DNA; non-covalent interactions of DNA with molecules such as groove binders or intercalators are not part of this review. Both terminal and internal modifications are covered, and the various points of attachment (nucleobase, sugar moiety or phosphodiester backbone) are compared. Using selected examples of the recent literature, the diversity of the functionalities that have been incorporated into DNA strands is discussed.
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Published date: 2011
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Local EPrints ID: 176841
URI: http://eprints.soton.ac.uk/id/eprint/176841
ISSN: 0306-0012
PURE UUID: 60c19a84-276f-449c-a06a-0c986c8e167d
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Date deposited: 11 Mar 2011 12:12
Last modified: 14 Mar 2024 02:51
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Author:
Thomas J. Bandy
Author:
Ashley Brewer
Author:
Jonathan R. Burns
Author:
Gabriella Marth
Author:
ThaoNguyen Nguyen
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