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Obstructive sleep apnea syndrome and fatty liver: association or causal link?

Obstructive sleep apnea syndrome and fatty liver: association or causal link?
Obstructive sleep apnea syndrome and fatty liver: association or causal link?
Obstructive sleep apnea (OSA) is a complex disorder that consists of upper airway obstruction, chronic intermittent hypoxia and sleep fragmentation. OSA is well known to be associated with hypoxia, insulin resistance and glucose intolerance, and these factors can occur in the presence or absence of obesity and metabolic syndrome. Although it is well established that insulin resistance, glucose intolerance and obesity occur frequently with non-alcoholic fatty liver disease (NAFLD), it is now becoming apparent that hypoxia might also be important in the development of NAFLD, and it is recognized that there is increased risk of NAFLD with OSA. This review discusses the association between OSA, NAFLD and cardiovascular disease, and describes the potential role of hypoxia in the development of NAFLD with OSA
1007-9327
4243-4252
Ahmed, M.H.
0dcfcd8b-55bc-48dc-9dbe-24df7fe58269
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Ahmed, M.H.
0dcfcd8b-55bc-48dc-9dbe-24df7fe58269
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c

Ahmed, M.H. and Byrne, C.D. (2010) Obstructive sleep apnea syndrome and fatty liver: association or causal link? World Journal of Gastroenterology, 16 (34), 4243-4252. (PMID:20818807)

Record type: Article

Abstract

Obstructive sleep apnea (OSA) is a complex disorder that consists of upper airway obstruction, chronic intermittent hypoxia and sleep fragmentation. OSA is well known to be associated with hypoxia, insulin resistance and glucose intolerance, and these factors can occur in the presence or absence of obesity and metabolic syndrome. Although it is well established that insulin resistance, glucose intolerance and obesity occur frequently with non-alcoholic fatty liver disease (NAFLD), it is now becoming apparent that hypoxia might also be important in the development of NAFLD, and it is recognized that there is increased risk of NAFLD with OSA. This review discusses the association between OSA, NAFLD and cardiovascular disease, and describes the potential role of hypoxia in the development of NAFLD with OSA

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Published date: 14 September 2010

Identifiers

Local EPrints ID: 176853
URI: http://eprints.soton.ac.uk/id/eprint/176853
ISSN: 1007-9327
PURE UUID: 5b2090f6-2520-4f3a-bbc6-ad754b8cf6ca
ORCID for C.D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 11 Mar 2011 14:04
Last modified: 03 Dec 2019 01:55

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