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The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction
The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction
The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.


2040-2503
345-348
Ting, Valeska P.
72559b76-c835-43eb-97e2-28f4b69e219c
Schmidtmann, Marc
a4fdd057-e08c-4b13-bc5d-a41181e8e17f
Henry, Paul F.
6ab0d6ca-bb2c-4286-9fad-1a5894dd8b75
Dann, Sandie E.
05f6d118-2661-431c-bf40-c414f96a24bc
Crisp, Jenna L.
8c9b605a-54e4-478a-b0d2-cb6a34348788
Wilson, Chick C.
4b5044d0-fb05-4d70-92b1-d12387c593a1
Weller, Mark T.
5be42713-fd58-4dc6-bc7a-86a801e201bc
Ting, Valeska P.
72559b76-c835-43eb-97e2-28f4b69e219c
Schmidtmann, Marc
a4fdd057-e08c-4b13-bc5d-a41181e8e17f
Henry, Paul F.
6ab0d6ca-bb2c-4286-9fad-1a5894dd8b75
Dann, Sandie E.
05f6d118-2661-431c-bf40-c414f96a24bc
Crisp, Jenna L.
8c9b605a-54e4-478a-b0d2-cb6a34348788
Wilson, Chick C.
4b5044d0-fb05-4d70-92b1-d12387c593a1
Weller, Mark T.
5be42713-fd58-4dc6-bc7a-86a801e201bc

Ting, Valeska P., Schmidtmann, Marc, Henry, Paul F., Dann, Sandie E., Crisp, Jenna L., Wilson, Chick C. and Weller, Mark T. (2010) The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction. MedChemComm, 1 (5), 345-348. (doi:10.1039/c0md00093k).

Record type: Article

Abstract

The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.


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Published date: 2010

Identifiers

Local EPrints ID: 176939
URI: http://eprints.soton.ac.uk/id/eprint/176939
ISSN: 2040-2503
PURE UUID: 2cdd64ba-0804-40a8-8302-9bffee813bf1

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Date deposited: 14 Mar 2011 09:44
Last modified: 03 Jan 2019 10:30

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Contributors

Author: Valeska P. Ting
Author: Marc Schmidtmann
Author: Paul F. Henry
Author: Sandie E. Dann
Author: Jenna L. Crisp
Author: Chick C. Wilson
Author: Mark T. Weller

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