Xanthine oxidase is a peroxynitrite synthase: newly identified roles for a very old enzyme
Xanthine oxidase is a peroxynitrite synthase: newly identified roles for a very old enzyme
Xanthine oxidase (XO) was first identified in 1902 by the German scientist Schardinger in bovine milk by following the hydroxylation of hypoxanthine to xanthine. Following this first discovery, the history of xanthine oxidase has followed the usual routes of investigation such as they were at the start of the 20th century. The electron donors and acceptors were identified and the constituents of the active sites were deduced. It turns out to be a classic, multicentred, redox enzyme.
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65-70
Millar, Timothy
ec88510c-ad88-49f6-8b2d-4277c84c1958
Kanczler, Janos
eb8db9ff-a038-475f-9030-48eef2b0559c
Bodamyali, Tulin
891aa0d1-20cd-4288-8c2c-5b369a00cf83
Blake, David
5e04d75b-8132-44fd-9565-114e1d604484
Stevens, Cliff
79241000-6e42-43e3-b005-7c369cc7c7e6
April 2002
Millar, Timothy
ec88510c-ad88-49f6-8b2d-4277c84c1958
Kanczler, Janos
eb8db9ff-a038-475f-9030-48eef2b0559c
Bodamyali, Tulin
891aa0d1-20cd-4288-8c2c-5b369a00cf83
Blake, David
5e04d75b-8132-44fd-9565-114e1d604484
Stevens, Cliff
79241000-6e42-43e3-b005-7c369cc7c7e6
Millar, Timothy, Kanczler, Janos, Bodamyali, Tulin, Blake, David and Stevens, Cliff
(2002)
Xanthine oxidase is a peroxynitrite synthase: newly identified roles for a very old enzyme.
Redox Report, 7 (2), .
(doi:10.1179/135100002125000280).
(PMID:12189051)
Abstract
Xanthine oxidase (XO) was first identified in 1902 by the German scientist Schardinger in bovine milk by following the hydroxylation of hypoxanthine to xanthine. Following this first discovery, the history of xanthine oxidase has followed the usual routes of investigation such as they were at the start of the 20th century. The electron donors and acceptors were identified and the constituents of the active sites were deduced. It turns out to be a classic, multicentred, redox enzyme.
&more...
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Published date: April 2002
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Local EPrints ID: 177001
URI: http://eprints.soton.ac.uk/id/eprint/177001
ISSN: 1351-0002
PURE UUID: 7a2a203f-01bf-45b2-874a-f17e3a81c4ca
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Date deposited: 14 Mar 2011 08:27
Last modified: 11 Jul 2024 01:43
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Author:
Timothy Millar
Author:
Janos Kanczler
Author:
Tulin Bodamyali
Author:
David Blake
Author:
Cliff Stevens
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