The University of Southampton
University of Southampton Institutional Repository

Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitude

Richardson, Cassandra, Hogan, Alexandra M., Bucks, Romola S., Baya, Ana, Virues-Ortega, Javier, Holloway, John W., Rose-Zerilli, Matthew, Palmer, Lyle J., Webster, Rebecca J., Kirkham, Fenella J. and Baldeweg, Torsten (2011) Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitude Clinical Neurophysiology, 122, (9), pp. 1726-1734. (doi:10.1016/j.clinph.2011.02.001). (PMID:21377415).

Record type: Article

Abstract

OBJECTIVE: Neurophysiological methods were used to study the effects of high altitude living on brain functions in a subgroup of participants of the Bolivian Children Living at Altitude (BoCLA) project. METHODS: Electroencephalogram (EEG), event-related potentials (ERP) and cerebral blood flow velocity (CBFV) were recorded in two groups of adolescents (aged 13-16years), living either at sea-level or high altitude (?3700m). RESULTS: Neuropsychological testing revealed no deficits in the high altitude group, despite significantly reduced blood oxygen saturation. In agreement, ERPs elicited by oddball target detection and choice reaction time tasks were not different between groups. In contrast, resting state EEG showed reductions in delta and beta frequency amplitudes in adolescents living at high altitude. The EEG attenuations were correlated with lower CBFV, and the EEG group differences diminished during task performance. CONCLUSIONS: No indication was found for negative sequelae of chronic hypoxia in adolescents born and living at an altitude of ?3700m, rather evidence for successful neurophysiological adaptation was found under such conditions. SIGNIFICANCE: Dynamic regulation of metabolic demand is one adaptive mechanism that preserves cognitive development at high altitude.

Full text not available from this repository.

More information

Published date: September 2011
Keywords: altitude, eeg, erp, adolescence, cognition

Identifiers

Local EPrints ID: 177941
URI: http://eprints.soton.ac.uk/id/eprint/177941
PURE UUID: 3f46a84d-4f25-4c60-9430-30cbb0f0072a
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 22 Mar 2011 15:35
Last modified: 18 Jul 2017 12:05

Export record

Altmetrics

Contributors

Author: Cassandra Richardson
Author: Alexandra M. Hogan
Author: Romola S. Bucks
Author: Ana Baya
Author: Javier Virues-Ortega
Author: Lyle J. Palmer
Author: Rebecca J. Webster
Author: Fenella J. Kirkham
Author: Torsten Baldeweg

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×