Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia
Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia
We have identified two novel ABL1 fusion genes in two patients with B-cell acute lymphoblastic leukaemia (ALL) associated with a t(3;9)(p12;q34) and a t(5;9)(q23;q34), respectively. Molecular analysis revealed a FOXP1-ABL1 fusion for the t(3;9) and a SNX2-ABL1 fusion for the t(5;9). The fusions were confirmed by specific amplification of the genomic breakpoints using reverse transcription polymerase chain reaction. The identification of ALL with rare ABL1 fusion partners is important because the leukaemia may respond to tyrosine kinase inhibitors in the same way as ALL patients with a classical BCR-ABL1 fusion gene.
abl1, foxp1, snx2, all, acute lymphoblastic leukaemia
43-46
Ernst, Thomas
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Score, Joannah
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Deininger, Michael
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Hidalgo-Curtis, Claire
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Lackie, Peter
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Ershler, William B.
faee5c31-f129-44c0-8ed2-23a8bee7bd0d
Goldman, John M.
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Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Grand, Francis H.
89bd846f-638a-4bda-b8a9-8a1989021b31
April 2011
Ernst, Thomas
96c7805b-c900-4545-9f93-1a83d789cb56
Score, Joannah
ea0db6ef-c17e-4915-b216-ac67c07b26b7
Deininger, Michael
a2ce09a6-39d6-472f-879b-a6e611c2e585
Hidalgo-Curtis, Claire
5aaa8cfa-7271-48ee-8538-27736ab3eaf2
Lackie, Peter
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Ershler, William B.
faee5c31-f129-44c0-8ed2-23a8bee7bd0d
Goldman, John M.
2632cc83-5866-46bd-914d-8450157fe689
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Grand, Francis H.
89bd846f-638a-4bda-b8a9-8a1989021b31
Ernst, Thomas, Score, Joannah, Deininger, Michael, Hidalgo-Curtis, Claire, Lackie, Peter, Ershler, William B., Goldman, John M., Cross, Nicholas C.P. and Grand, Francis H.
(2011)
Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia.
British Journal of Haematology, 153 (1), .
(doi:10.1111/j.1365-2141.2010.08457.x).
Abstract
We have identified two novel ABL1 fusion genes in two patients with B-cell acute lymphoblastic leukaemia (ALL) associated with a t(3;9)(p12;q34) and a t(5;9)(q23;q34), respectively. Molecular analysis revealed a FOXP1-ABL1 fusion for the t(3;9) and a SNX2-ABL1 fusion for the t(5;9). The fusions were confirmed by specific amplification of the genomic breakpoints using reverse transcription polymerase chain reaction. The identification of ALL with rare ABL1 fusion partners is important because the leukaemia may respond to tyrosine kinase inhibitors in the same way as ALL patients with a classical BCR-ABL1 fusion gene.
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Published date: April 2011
Keywords:
abl1, foxp1, snx2, all, acute lymphoblastic leukaemia
Identifiers
Local EPrints ID: 178043
URI: http://eprints.soton.ac.uk/id/eprint/178043
ISSN: 0007-1048
PURE UUID: 95cac1bb-7994-4021-8d4d-cd308b652955
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Date deposited: 22 Mar 2011 14:58
Last modified: 15 Mar 2024 02:46
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Contributors
Author:
Thomas Ernst
Author:
Joannah Score
Author:
Michael Deininger
Author:
Claire Hidalgo-Curtis
Author:
William B. Ershler
Author:
John M. Goldman
Author:
Francis H. Grand
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