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Laser-induced damage and recovery of plasmonically targeted human endothelial cells

Laser-induced damage and recovery of plasmonically targeted human endothelial cells
Laser-induced damage and recovery of plasmonically targeted human endothelial cells
Laser-induced techniques that employ the surface plasmon resonances of nanoparticles have recently been introduced as an effective therapeutic tool for destroying tumor cells. Here, we adopt a low-intensity laser-induced technique to manipulate the damage and repair of a vital category of noncancerous cells, human endothelial cells. Endothelial cells construct the interior of blood vessels and play a pivotal role in angiogenesis. The degree of damage and repair of the cells is shown to be influenced by laser illumination in the presence of gold nanoparticles of different morphologies, which either target the cellular membrane or are endocytosed. A pronounced influence of the plasmonic nanoparticle laser treatment on the expression of critical angiogenic genes is shown. Our results show that plasmon-mediated mild laser treatment, combined with specific targeting of cellular membranes, enables new routes for controlling cell permeability and gene regulation in endothelial cells.
gold nanoparticles, endothelium, peptides, hyperthermia, laser treatment, plasmon
1530-6984
1358-1363
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Sanchez-Elsner, Tilman
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Sanchez-Elsner, Tilman
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7

Bartczak, Dorota, Muskens, Otto L., Millar, Timothy M., Sanchez-Elsner, Tilman and Kanaras, Antonios G. (2011) Laser-induced damage and recovery of plasmonically targeted human endothelial cells. Nano Letters, 11 (3), 1358-1363. (doi:10.1021/nl104528s). (PMID:21322611)

Record type: Article

Abstract

Laser-induced techniques that employ the surface plasmon resonances of nanoparticles have recently been introduced as an effective therapeutic tool for destroying tumor cells. Here, we adopt a low-intensity laser-induced technique to manipulate the damage and repair of a vital category of noncancerous cells, human endothelial cells. Endothelial cells construct the interior of blood vessels and play a pivotal role in angiogenesis. The degree of damage and repair of the cells is shown to be influenced by laser illumination in the presence of gold nanoparticles of different morphologies, which either target the cellular membrane or are endocytosed. A pronounced influence of the plasmonic nanoparticle laser treatment on the expression of critical angiogenic genes is shown. Our results show that plasmon-mediated mild laser treatment, combined with specific targeting of cellular membranes, enables new routes for controlling cell permeability and gene regulation in endothelial cells.

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nl104528s - Other
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Published date: 15 February 2011
Keywords: gold nanoparticles, endothelium, peptides, hyperthermia, laser treatment, plasmon
Organisations: Quantum, Light & Matter Group

Identifiers

Local EPrints ID: 178463
URI: https://eprints.soton.ac.uk/id/eprint/178463
ISSN: 1530-6984
PURE UUID: 9c88ffdd-e933-4a1d-ba0e-456728febc8f
ORCID for Otto L. Muskens: ORCID iD orcid.org/0000-0003-0693-5504
ORCID for Timothy M. Millar: ORCID iD orcid.org/0000-0002-4539-2445
ORCID for Antonios G. Kanaras: ORCID iD orcid.org/0000-0002-9847-6706

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Date deposited: 29 Mar 2011 15:30
Last modified: 12 Nov 2019 01:45

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