Laser-induced damage and recovery of plasmonically targeted human endothelial cells

Bartczak, Dorota, Muskens, Otto L., Millar, Timothy M., Sanchez-Elsner, Tilman and Kanaras, Antonios G. (2011) Laser-induced damage and recovery of plasmonically targeted human endothelial cells Nano Letters, 11, (3), pp. 1358-1363. (doi:10.1021/nl104528s). (PMID:21322611).


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Laser-induced techniques that employ the surface plasmon resonances of nanoparticles have recently been introduced as an effective therapeutic tool for destroying tumor cells. Here, we adopt a low-intensity laser-induced technique to manipulate the damage and repair of a vital category of noncancerous cells, human endothelial cells. Endothelial cells construct the interior of blood vessels and play a pivotal role in angiogenesis. The degree of damage and repair of the cells is shown to be influenced by laser illumination in the presence of gold nanoparticles of different morphologies, which either target the cellular membrane or are endocytosed. A pronounced influence of the plasmonic nanoparticle laser treatment on the expression of critical angiogenic genes is shown. Our results show that plasmon-mediated mild laser treatment, combined with specific targeting of cellular membranes, enables new routes for controlling cell permeability and gene regulation in endothelial cells.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1021/nl104528s
ISSNs: 1530-6984 (print)
Keywords: gold nanoparticles, endothelium, peptides, hyperthermia, laser treatment, plasmon

ePrint ID: 178463
Date :
Date Event
15 February 2011Published
Date Deposited: 29 Mar 2011 15:30
Last Modified: 18 Apr 2017 02:37
Further Information:Google Scholar

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