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Furosemide in the treatment of phosgene induced acute lung injury

Grainge, C., Smith, A.J., Jugg, B.J., Fairhall, S.J., Mann, T., Perrott, R., Jenner, J., Millar, T.M. and Rice, P. (2010) Furosemide in the treatment of phosgene induced acute lung injury Journal of the Royal Army Medical Corps, 156, (4), pp. 245-250. (PMID:21275359).

Record type: Article


Method: Using previously validated methods, 16 anaesthetised large white pigs were exposed to phosgene (target inhaled dose 0.3 mg kg(-1)), established on mechanical ventilation and randomised to treatment with either nebulised furosemide (4 ml of 10 mg x ml(-1) solution) or saline control. Treatments were given at 1, 3, 5, 7, 9, 12, 16 and 20 hours post phosgene exposure; the animals were monitored to 24 hours following phosgene exposure.

Results: Furosemide treatment had no effect on survival, and had a deleterious effect on PaO2: FiO2 ratio between 19 and 24 hours. All other measures investigated were unaffected by treatment.

Conclusion: Nebulised furosemide treatment following phosgene induced acute lung injury does not improve survival and worsens PaO2: FiO2 ratio. Nebulised furosemide should be avoided following phosgene exposure

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Published date: December 2010


Local EPrints ID: 178475
ISSN: 0035-8665
PURE UUID: 576032e0-7736-4f07-a743-1f937cc4a35f

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Date deposited: 24 Mar 2011 16:04
Last modified: 18 Jul 2017 12:04

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Author: C. Grainge
Author: A.J. Smith
Author: B.J. Jugg
Author: S.J. Fairhall
Author: T. Mann
Author: R. Perrott
Author: J. Jenner
Author: T.M. Millar
Author: P. Rice

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