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Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions

Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions
Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions
Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Generation of nitric oxide is not detectable under normoxic conditions and is inhibited by the molybdenum site-specific inhibitors, oxypurinol and (-)BOF 4272. These enzymic reactions provide a mechanism for generation of NO under hypoxic conditions where nitric oxide synthase does not function, suggesting a vasodilatory role in ischaemia.

xanthine oxidoreductase, nitric oxide, nitrate, nitrite
0014-5793
225-228
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958

Millar, Timothy M. (1998) Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions. FEBS Letters, 427 (2), 225-228. (doi:10.1016/S0014-5793(98)00430-X). (PMID:9607316)

Record type: Article

Abstract

Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Generation of nitric oxide is not detectable under normoxic conditions and is inhibited by the molybdenum site-specific inhibitors, oxypurinol and (-)BOF 4272. These enzymic reactions provide a mechanism for generation of NO under hypoxic conditions where nitric oxide synthase does not function, suggesting a vasodilatory role in ischaemia.

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More information

Published date: 8 May 1998
Keywords: xanthine oxidoreductase, nitric oxide, nitrate, nitrite

Identifiers

Local EPrints ID: 178679
URI: https://eprints.soton.ac.uk/id/eprint/178679
ISSN: 0014-5793
PURE UUID: ea323ce9-2b96-4f5c-9189-791b78131a5a
ORCID for Timothy M. Millar: ORCID iD orcid.org/0000-0002-4539-2445

Catalogue record

Date deposited: 25 Mar 2011 14:30
Last modified: 06 Jun 2018 12:39

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