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Review: The chemistry of retinal transplantation: the influence of polymer scaffold properties on retinal cell adhesion and control

Record type: Article

Age-related macular degeneration is the most common cause of blindness in the UK. Cellular replacement of retinal pigment epithelium cells is a potential therapeutic option to treat the cellular loss and dysfunction which is characteristic of age-related macular degeneration and other progressive retinopathies. A supportive scaffold, natural or artificial, may be required to facilitate cell delivery to the eye. Research to improve the biomimetic properties of such scaffolds, in order to optimise cell attachment and functionality following implantation, is ongoing. This short review will focus on the potential of biomaterials for ocular tissue engineering and how surface modification and the physical properties of these scaffolds can be tailored to help realise the full clinical potential of retinal pigment epithelium cell transplantation.

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Citation

Treharne, Andrew J, Grossel, Martin C, Lotery, Andrew J and Thomson, Heather A (2010) Review: The chemistry of retinal transplantation: the influence of polymer scaffold properties on retinal cell adhesion and control British Journal of Ophthalmology (doi:10.1136/bjo.2010.184002). (PMID:20807710).

More information

Published date: 31 August 2010

Identifiers

Local EPrints ID: 179765
URI: http://eprints.soton.ac.uk/id/eprint/179765
ISSN: 0007-1161
PURE UUID: 55756758-2b01-4207-88c2-b5822602d411
ORCID for Martin C Grossel: ORCID iD orcid.org/0000-0001-7469-6854

Catalogue record

Date deposited: 04 Apr 2011 13:11
Last modified: 18 Jul 2017 12:02

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Contributors

Author: Andrew J Treharne
Author: Andrew J Lotery
Author: Heather A Thomson

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