The University of Southampton
University of Southampton Institutional Repository

The molecular biology of desmosomes and hemidesmosomes: ?What's in a name?'

Legan, P.K., Collins, J.E. and Garrod, D.R. (1992) The molecular biology of desmosomes and hemidesmosomes: ?What's in a name?' BioEssays, 14, (6), pp. 385-393. (doi:10.1002/(ISSN)1521-1878). (PMID:1503553).

Record type: Article


Desmosomes are junctions involved in intercellular adhesion of epithelial cells and hemidesmosomes are junctions involved in adhesion of epithelia to basement membranes. Both are characterised at the ultrastructural level by dense cytoplasmic plaques which are linked to the intermediate filament cytoskeleton of the cells. The plaques strongly resemble each other suggesting a relationship between the two kinds of junctions, as implied by their names. Recent characterisation of the molecular components of the junctions shows they are, in fact, quite unrelated implying that structural similarity is fortuitous. The molecular biology raises many fascinating problems relating to their structure and function.

Full text not available from this repository.

More information

Published date: June 1992


Local EPrints ID: 179801
ISSN: 0265-9247
PURE UUID: dd533435-36f1-4d47-a9cc-7f03d739ce7a

Catalogue record

Date deposited: 04 Apr 2011 13:18
Last modified: 18 Jul 2017 12:02

Export record



Author: P.K. Legan
Author: J.E. Collins
Author: D.R. Garrod

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.