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The molecular biology of desmosomes and hemidesmosomes: ?What's in a name?'

Legan, P.K., Collins, J.E. and Garrod, D.R. (1992) The molecular biology of desmosomes and hemidesmosomes: ?What's in a name?' BioEssays, 14, (6), pp. 385-393. (doi:10.1002/(ISSN)1521-1878). (PMID:1503553).

Record type: Article

Abstract

Desmosomes are junctions involved in intercellular adhesion of epithelial cells and hemidesmosomes are junctions involved in adhesion of epithelia to basement membranes. Both are characterised at the ultrastructural level by dense cytoplasmic plaques which are linked to the intermediate filament cytoskeleton of the cells. The plaques strongly resemble each other suggesting a relationship between the two kinds of junctions, as implied by their names. Recent characterisation of the molecular components of the junctions shows they are, in fact, quite unrelated implying that structural similarity is fortuitous. The molecular biology raises many fascinating problems relating to their structure and function.

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Published date: June 1992

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Local EPrints ID: 179801
URI: http://eprints.soton.ac.uk/id/eprint/179801
ISSN: 0265-9247
PURE UUID: dd533435-36f1-4d47-a9cc-7f03d739ce7a

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Date deposited: 04 Apr 2011 13:18
Last modified: 18 Jul 2017 12:02

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Contributors

Author: P.K. Legan
Author: J.E. Collins
Author: D.R. Garrod

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