The University of Southampton
University of Southampton Institutional Repository

Anti-angiogenic effects of dietary isothiocyanates: mechanisms of action and implications for human health

Anti-angiogenic effects of dietary isothiocyanates: mechanisms of action and implications for human health
Anti-angiogenic effects of dietary isothiocyanates: mechanisms of action and implications for human health
Isothiocyanates (ITCs) are electrophilic compounds derived from plants and are thought to play a major role in the potential chemopreventive effects associated with high intake of cruciferous vegetables. ITCs are also being evaluated for chemotherapeutic activity in early phase clinical trials. In addition to their effects on carcinogen metabolism and cancer cell survival and proliferation, ITCs have been shown to effectively interfere with angiogenesis in vitro and in vivo. Angiogenesis is the development of a new blood supply from existing vasculature and is required for tumours to develop beyond a small size limit determined by the diffusion limit for oxygen. Inhibition of angiogenesis may play a key role in the potential chemopreventive/chemotherapeutic activity of ITCs. In this review we highlight recent data demonstrating that ITCs have anti-angiogenic activity and identify potential molecular targets for these effects, including hypoxia-inducible factor (HIF), nuclear factor ?B (NF-?B), activator protein 1 (AP1) and tubulin. We also discuss these findings in light of the potential chemopreventive/chemotherapeutic effects of ITCs.
0006-2952
327-336
Cavell, Breeze E
d193659a-9a2c-4a22-8ba4-81d9d98ceb9b
Syed Alwi, Sharifah S
85a3f6d5-d10f-4c3f-91c1-930c164e7863
Donlevy, Alison
c088848d-cbdc-4c82-9c7f-56bc4bde2317
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Cavell, Breeze E
d193659a-9a2c-4a22-8ba4-81d9d98ceb9b
Syed Alwi, Sharifah S
85a3f6d5-d10f-4c3f-91c1-930c164e7863
Donlevy, Alison
c088848d-cbdc-4c82-9c7f-56bc4bde2317
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394

Cavell, Breeze E, Syed Alwi, Sharifah S, Donlevy, Alison and Packham, Graham (2011) Anti-angiogenic effects of dietary isothiocyanates: mechanisms of action and implications for human health. Biochemical Pharmacology, 81 (3), 327-336. (doi:10.1016/j.bcp.2010.10.005). (PMID:20955689)

Record type: Article

Abstract

Isothiocyanates (ITCs) are electrophilic compounds derived from plants and are thought to play a major role in the potential chemopreventive effects associated with high intake of cruciferous vegetables. ITCs are also being evaluated for chemotherapeutic activity in early phase clinical trials. In addition to their effects on carcinogen metabolism and cancer cell survival and proliferation, ITCs have been shown to effectively interfere with angiogenesis in vitro and in vivo. Angiogenesis is the development of a new blood supply from existing vasculature and is required for tumours to develop beyond a small size limit determined by the diffusion limit for oxygen. Inhibition of angiogenesis may play a key role in the potential chemopreventive/chemotherapeutic activity of ITCs. In this review we highlight recent data demonstrating that ITCs have anti-angiogenic activity and identify potential molecular targets for these effects, including hypoxia-inducible factor (HIF), nuclear factor ?B (NF-?B), activator protein 1 (AP1) and tubulin. We also discuss these findings in light of the potential chemopreventive/chemotherapeutic effects of ITCs.

Full text not available from this repository.

More information

Published date: 1 February 2011

Identifiers

Local EPrints ID: 180131
URI: https://eprints.soton.ac.uk/id/eprint/180131
ISSN: 0006-2952
PURE UUID: 23b1f50f-a853-47a0-a7be-46b16e4855d1
ORCID for Graham Packham: ORCID iD orcid.org/0000-0002-9232-5691

Catalogue record

Date deposited: 05 Apr 2011 12:45
Last modified: 31 Jan 2019 01:37

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×