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Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes

Diniz, Daniel G., Foro, César A. R., Rego, Carla M. D., Gloria, David A., De Oliveira, Fabio R. R., Paes, Juliana M. P., De Sousa, Aline A., Tokuhashi, Tatyana P., Trindade, Lucas S., Turiel, Maíra C. P., Vasconcelos, Erick G. R., Torres, João B., Cunnigham, Colm, Perry, Victor Hugh, Da Costa Vasconcelos, Pedro F. and Diniz, Cristovam W. P. (2010) Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes European Journal of Neuroscience, 32, (3), pp. 509-519. (doi:10.1111/j.1460-9568.2010.07296.x). (PMID:20704596).

Record type: Article

Abstract

Environmental and age-related effects on learning and memory were analysed and compared with changes observed in astrocyte laminar distribution in the dentate gyrus. Aged (20 months) and young (6 months) adult female albino Swiss mice were housed from weaning either in impoverished conditions or in enriched conditions, and tested for episodic-like and water maze spatial memories. After these behavioral tests, brain hippocampal sections were immunolabeled for glial fibrillary acid protein to identify astrocytes. The effects of environmental enrichment on episodic-like memory were not dependent on age, and may protect water maze spatial learning and memory from declines induced by aging or impoverished environment. In the dentate gyrus, the number of astrocytes increased with both aging and enriched environment in the molecular layer, increased only with aging in the polymorphic layer, and was unchanged in the granular layer. We suggest that long-term experience-induced glial plasticity by enriched environment may represent at least part of the circuitry groundwork for improvements in behavioral performance in the aged mice brain

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Published date: August 2010

Identifiers

Local EPrints ID: 180195
URI: http://eprints.soton.ac.uk/id/eprint/180195
ISSN: 0953-816X
PURE UUID: 66206137-1fe1-4b2d-a834-046290591cd5

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Date deposited: 06 Apr 2011 08:20
Last modified: 18 Jul 2017 12:01

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Contributors

Author: Daniel G. Diniz
Author: César A. R. Foro
Author: Carla M. D. Rego
Author: David A. Gloria
Author: Fabio R. R. De Oliveira
Author: Juliana M. P. Paes
Author: Aline A. De Sousa
Author: Tatyana P. Tokuhashi
Author: Lucas S. Trindade
Author: Maíra C. P. Turiel
Author: Erick G. R. Vasconcelos
Author: João B. Torres
Author: Colm Cunnigham
Author: Pedro F. Da Costa Vasconcelos
Author: Cristovam W. P. Diniz

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