Contribution of systemic inflammation to chronic neurodegeneration

Perry, V Hugh (2010) Contribution of systemic inflammation to chronic neurodegeneration Acta Neuropathological, 120, (3), pp. 277-286. (doi:10.1007/s00401-010-0722-x). (PMID:20644946).


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Systemic infection or inflammation gives rise to signals that communicate with the brain and leads to changes in metabolism and behaviour collectively known as sickness behaviour. In healthy young individuals, these changes are normally transient with no long-term consequences. The microglia are involved in the immune to brain signalling pathways. In the aged or diseased brain, the microglia have a primed phenotype as a consequence of changes in their local microenvironment. Systemic inflammation impacts on these primed microglia and switches them from a relatively benign to an aggressive phenotype with the enhanced synthesis of pro-inflammatory mediators. Recent evidence suggests that systemic inflammation contributes to the exacerbation of acute symptoms of chronic neurodegenerative disease and may accelerate disease progression. The normal homeostatic role that microglia play in signalling about systemic infections and inflammation becomes maladaptive in the aged and diseased brain and this offers a route to therapeutic intervention. Prompt treatment of systemic inflammation or blockade of signalling pathways from the periphery to the brain may help to slow neurodegeneration and improve the quality of life for individuals suffering from chronic neurodegenerative disease.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1007/s00401-010-0722-x
ISSNs: 1432-0533 (print)
ePrint ID: 180205
Date :
Date Event
September 2010Published
Date Deposited: 06 Apr 2011 07:48
Last Modified: 18 Apr 2017 02:32
Further Information:Google Scholar

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