Reactive hypertrophy of synaptic varicosities within the hippocampus of prion-infected mice
Reactive hypertrophy of synaptic varicosities within the hippocampus of prion-infected mice
Prion diseases are characteristically accompanied by extensive synaptic pathology that can occur during the preclinical phase of the disease and, in animal models, correlates with the first decline of hippocampus-dependent cognitive functions. This pathology is defined by abnormally shaped synapses in which the postsynaptic membrane modifies its curvature and potentially engulfs the juxtaposed presynaptic membrane. Using the intrahippocampally injected ME7 prion model, we further detailed the structural alterations of the population of ostensibly intact synaptic compartments within the hippocampus during this period of extensive synaptic loss. A disease stage-dependent increase in the average PSD (postsynaptic density) area, the average length of the active zone and the average number of synaptic vesicles indicated that the synapses that were visualized as the animal progressed to end-stage disease were undergoing hypertrophy. Similar findings in samples from AD (Alzheimer's disease) patients, aged and senile individuals, and animal models of neurodegenerative diseases suggest synaptic swelling as synaptic loss is initiated and/or compensatory reaction to counteract the synaptic loss
471-475
Sisková, Zuzana
6304f831-f737-470a-86b6-3e94c3d805bc
Sanyal, Nik K
6cbab950-6379-418a-99fb-2a33da45c11d
Orban, Adam
5b3365f8-1559-4c59-8e41-1164beac19ef
O'Connor, Vincent
8021b06c-01a0-4925-9dde-a61c8fe278ca
Perry, V Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
April 2010
Sisková, Zuzana
6304f831-f737-470a-86b6-3e94c3d805bc
Sanyal, Nik K
6cbab950-6379-418a-99fb-2a33da45c11d
Orban, Adam
5b3365f8-1559-4c59-8e41-1164beac19ef
O'Connor, Vincent
8021b06c-01a0-4925-9dde-a61c8fe278ca
Perry, V Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Sisková, Zuzana, Sanyal, Nik K, Orban, Adam, O'Connor, Vincent and Perry, V Hugh
(2010)
Reactive hypertrophy of synaptic varicosities within the hippocampus of prion-infected mice.
Biochemical Society Transactions, 38 (2), .
(doi:10.1042/BST0380471).
(PMID:20298205)
Abstract
Prion diseases are characteristically accompanied by extensive synaptic pathology that can occur during the preclinical phase of the disease and, in animal models, correlates with the first decline of hippocampus-dependent cognitive functions. This pathology is defined by abnormally shaped synapses in which the postsynaptic membrane modifies its curvature and potentially engulfs the juxtaposed presynaptic membrane. Using the intrahippocampally injected ME7 prion model, we further detailed the structural alterations of the population of ostensibly intact synaptic compartments within the hippocampus during this period of extensive synaptic loss. A disease stage-dependent increase in the average PSD (postsynaptic density) area, the average length of the active zone and the average number of synaptic vesicles indicated that the synapses that were visualized as the animal progressed to end-stage disease were undergoing hypertrophy. Similar findings in samples from AD (Alzheimer's disease) patients, aged and senile individuals, and animal models of neurodegenerative diseases suggest synaptic swelling as synaptic loss is initiated and/or compensatory reaction to counteract the synaptic loss
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Published date: April 2010
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Local EPrints ID: 180211
URI: http://eprints.soton.ac.uk/id/eprint/180211
ISSN: 0300-5127
PURE UUID: 19ace411-a53a-469e-b2ad-69a923f367fb
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Date deposited: 06 Apr 2011 11:05
Last modified: 15 Mar 2024 03:04
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Author:
Zuzana Sisková
Author:
Nik K Sanyal
Author:
Adam Orban
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