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Trapping and micromanipulation using ultrasonic fields and dual ultrasonic/magnetic forces

Hill, Martyn, Glynne-Jones, Peter, Harris, Nicholas R., Boltryk, Rosemary J., Stanley, Christopher and Bond, Damian (2010) Trapping and micromanipulation using ultrasonic fields and dual ultrasonic/magnetic forces In Optical Trapping and Optical Micromanipulation VII. vol. 7762, The International Society for Optical Engineering.. (doi:10.1117/12.863548).

Record type: Conference or Workshop Item (Paper)


Ultrasonic fields can be used to trap and manipulate micron-scale particles and second-phase fluids, utilising energy densities that do not impair cell viability. The technology can be seen as complementary to optical trapping as the size of the potential wells generated can be relatively large, making ultrasound suitable for the formation and manipulation of cell agglomerates, but less suitable for the manipulation of individual cells. This paper discusses physical phenomena associated with ultrasonic manipulation, including radiation forces, cavitation, and acoustic streaming. The technology is well suited to integration within "Lab on a Chip" devices and can involve excitation by plane, focussed, flexural, or surface acoustic waves. Example applications of resonators are discussed including particle filtration and concentration, cell washing, and biosensor enhancement. A recently developed device that uses both ultrasonic and magnetic forces to enhance the detection of tuberculosis bacteria using magnetic beads is discussed in detail. This approach uses ultrasonic levitation forces to overcome some of the issues associated with purely magnetic trapping. The technology has been implemented in a device in which the main fluidic components are disposable to allow for low production costs and improved control of biohazards

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Published date: 2010
Venue - Dates: Optical Trapping and Optical Micromanipulation VII, 2010-08-01 - 2010-08-05


Local EPrints ID: 180669
ISBN: 9780819482587
PURE UUID: 38c9136c-4223-4dd6-b620-d3611f568955
ORCID for Martyn Hill: ORCID iD
ORCID for Peter Glynne-Jones: ORCID iD
ORCID for Nicholas R. Harris: ORCID iD

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Date deposited: 13 Apr 2011 10:20
Last modified: 18 Jul 2017 12:00

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Author: Martyn Hill ORCID iD
Author: Nicholas R. Harris ORCID iD
Author: Rosemary J. Boltryk
Author: Christopher Stanley
Author: Damian Bond

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