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Absence of association of a SNP in the TERT-CLPTM1L locus with age-related phenotypes in a large multi-cohort study: HALCyon program

Absence of association of a SNP in the TERT-CLPTM1L locus with age-related phenotypes in a large multi-cohort study: HALCyon program
Absence of association of a SNP in the TERT-CLPTM1L locus with age-related phenotypes in a large multi-cohort study: HALCyon program
Several age-related traits are associated with shorter telomeres, the structures that cap the end of linear chromosomes. A common polymorphism near the telomere maintenance gene TERT has been associated with several cancers, but relationships with other aging traits such as physical capability have not been reported. As part of the Healthy Ageing across the Life Course (HALCyon) collaborative research programme, men and women aged between 44 and 90 years from nine UK cohorts were genotyped for the single-nucleotide polymorphism (SNP) rs401681. We then investigated relationships between the SNP and 30 age-related phenotypes, including cognitive and physical capability, blood lipid levels and lung function, pooling within-study genotypic effects in meta-analyses. No significant associations were found between the SNP and any of the cognitive performance tests (e.g. pooled beta per T allele for word recall z-score = 0.02, 95% CI: ?0.01 to 0.04, P-value = 0.12, n = 18 737), physical performance tests (e.g. pooled beta for grip strength = ?0.02, 95% CI: ?0.045 to 0.006, P-value = 0.14, n = 11 711), blood pressure, lung function or blood test measures. Similarly, no differences in observations were found when considering follow-up measures of cognitive or physical performance after adjusting for its measure at an earlier assessment. The lack of associations between SNP rs401681 and a wide range of age-related phenotypes investigated in this large multicohort study suggests that while this SNP may be associated with cancer, it is not an important contributor to other markers of aging.

aging, cognition, middle-aged, physical, telomere
1474-9718
520-532
Alfred, Tamuno
a74abf26-a2cf-4a0d-9abf-6e9507cfad7a
Ben-Shlomo, Yaov
172ff43e-8a2d-4731-a97e-c5ed7f18c64e
Cooper, Rachel
24a4a55a-ccc1-4961-9b76-b89aa4eb2fdf
Hardy, Rebecca
99fecbaf-fc92-4354-aa02-cb904dd2bd32
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
Elliott, Jane
7797aa8c-2fe3-44d3-bfcd-d207ded2d228
Gunnell, David
d525f7e5-7447-43c8-84b7-a122b60b3c54
Harris, Sarah E.
925adc32-c478-44a2-84c0-1c7eefa8dfc8
Kivimaki, Mika
be7a46cc-c9fe-48f5-b998-886f6dfba451
Kumari, Meena
fc42bd66-3f7c-4f72-8f7b-d9cb40900b3d
Martin, Richard M.
ce5c4184-4432-4435-bd1e-221f665d42d8
Power, Chris
21b17ff2-fabc-4782-9081-ab114c99a3a4
Sayer, Avan A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Starr, John M.
92fc6cf8-b0f7-47dc-93d8-8fd246d40585
Kuh, Diana
4f3b51aa-21a0-4d68-be14-e1ed75448aaf
Day, Ian N.
083567b2-eb88-4491-b966-57fcfaf6321d
HALCyon Study Team
Alfred, Tamuno
a74abf26-a2cf-4a0d-9abf-6e9507cfad7a
Ben-Shlomo, Yaov
172ff43e-8a2d-4731-a97e-c5ed7f18c64e
Cooper, Rachel
24a4a55a-ccc1-4961-9b76-b89aa4eb2fdf
Hardy, Rebecca
99fecbaf-fc92-4354-aa02-cb904dd2bd32
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
Elliott, Jane
7797aa8c-2fe3-44d3-bfcd-d207ded2d228
Gunnell, David
d525f7e5-7447-43c8-84b7-a122b60b3c54
Harris, Sarah E.
925adc32-c478-44a2-84c0-1c7eefa8dfc8
Kivimaki, Mika
be7a46cc-c9fe-48f5-b998-886f6dfba451
Kumari, Meena
fc42bd66-3f7c-4f72-8f7b-d9cb40900b3d
Martin, Richard M.
ce5c4184-4432-4435-bd1e-221f665d42d8
Power, Chris
21b17ff2-fabc-4782-9081-ab114c99a3a4
Sayer, Avan A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Starr, John M.
92fc6cf8-b0f7-47dc-93d8-8fd246d40585
Kuh, Diana
4f3b51aa-21a0-4d68-be14-e1ed75448aaf
Day, Ian N.
083567b2-eb88-4491-b966-57fcfaf6321d

Alfred, Tamuno, Ben-Shlomo, Yaov, Cooper, Rachel, Hardy, Rebecca, Cooper, Cyrus, Deary, Ian J., Elliott, Jane, Gunnell, David, Harris, Sarah E., Kivimaki, Mika, Kumari, Meena, Martin, Richard M., Power, Chris, Sayer, Avan A., Starr, John M., Kuh, Diana and Day, Ian N. , HALCyon Study Team (2011) Absence of association of a SNP in the TERT-CLPTM1L locus with age-related phenotypes in a large multi-cohort study: HALCyon program. Aging Cell, 10 (3), 520-532. (doi:10.1111/j.1474-9726.2011.00687.x). (PMID:21332924)

Record type: Article

Abstract

Several age-related traits are associated with shorter telomeres, the structures that cap the end of linear chromosomes. A common polymorphism near the telomere maintenance gene TERT has been associated with several cancers, but relationships with other aging traits such as physical capability have not been reported. As part of the Healthy Ageing across the Life Course (HALCyon) collaborative research programme, men and women aged between 44 and 90 years from nine UK cohorts were genotyped for the single-nucleotide polymorphism (SNP) rs401681. We then investigated relationships between the SNP and 30 age-related phenotypes, including cognitive and physical capability, blood lipid levels and lung function, pooling within-study genotypic effects in meta-analyses. No significant associations were found between the SNP and any of the cognitive performance tests (e.g. pooled beta per T allele for word recall z-score = 0.02, 95% CI: ?0.01 to 0.04, P-value = 0.12, n = 18 737), physical performance tests (e.g. pooled beta for grip strength = ?0.02, 95% CI: ?0.045 to 0.006, P-value = 0.14, n = 11 711), blood pressure, lung function or blood test measures. Similarly, no differences in observations were found when considering follow-up measures of cognitive or physical performance after adjusting for its measure at an earlier assessment. The lack of associations between SNP rs401681 and a wide range of age-related phenotypes investigated in this large multicohort study suggests that while this SNP may be associated with cancer, it is not an important contributor to other markers of aging.

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Published date: 7 April 2011
Keywords: aging, cognition, middle-aged, physical, telomere
Organisations: Faculty of Medicine, Medicine

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Local EPrints ID: 180679
URI: https://eprints.soton.ac.uk/id/eprint/180679
ISSN: 1474-9718
PURE UUID: e31c032c-bf35-4a86-a6ff-63ae22ceadfe
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 12 Apr 2011 09:26
Last modified: 06 Jun 2018 13:00

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Contributors

Author: Tamuno Alfred
Author: Yaov Ben-Shlomo
Author: Rachel Cooper
Author: Rebecca Hardy
Author: Cyrus Cooper ORCID iD
Author: Ian J. Deary
Author: Jane Elliott
Author: David Gunnell
Author: Sarah E. Harris
Author: Mika Kivimaki
Author: Meena Kumari
Author: Richard M. Martin
Author: Chris Power
Author: Avan A. Sayer
Author: John M. Starr
Author: Diana Kuh
Author: Ian N. Day

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