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Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort study

Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort study
Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort study
Background: trends in the prevalence of eczema in the course of childhood and adolescence are not clear although often a net remission during childhood is assumed.

Objectives: to investigate the dynamics of change in eczema from 1 to 18 years in a prospective study and to understand the influence of gender and atopy.

Methods: detailed information regarding eczema were collected at ages 1, 2, 4, 10 and 18 years from the 1989 Isle of Wight birth cohort (n=1456). Skin prick testing was performed at 4, 10 and 18 years of age. The 12-month period prevalence, positive and negative transitions (defined as change in disease status in two consecutive study assessments) were stratified by gender and atopic status.

Results: the period prevalence of eczema from birth to 18 years of age remained relatively constant (11.9–14.2%) with minimal remission. Up to 10 years of age, gender did not influence prevalence. From 10 to 18 years, eczema became more prevalent among girls (16.3% for girls vs. 8.3% for boys, P<0.001) as a result of a greater positive transition in girls (9.4% for girls vs. 4.3% for boys, P=0.001) and greater negative transition in boys (65.4% for boys vs. 50% for girls, P=0.04). The higher positive transition of eczema in girls was most pronounced for non-atopic eczema (5.9% for girls vs. 1.5% for boys, P=0.002).

Conclusions: we found only a minimal reduction in the prevalence of eczema during childhood and adolescence. During adolescence, more girls develop eczema and more boys outgrow it suggesting a role for gender-specific pubertal factors
0954-7894
1776-1784
Ziyab, A.H.
288d35a2-e782-49f8-b2e8-fdb0290a7c00
Raza, A.
28cf549d-f7e9-4f43-b60e-8c7866cb1d1d
Karmaus, W.
d78616d6-bc9c-4664-a461-7c0d0be5e39e
Tongue, N.
f370229f-98f1-4a21-8232-a0a4efd82ec6
Zhang, H.
49b0dd51-9e3e-4c73-ac6f-af1bd3a9bcd0
Matthews, S.
79b68905-6033-4cf8-8a36-af956611f854
Arshad, S.H.
917e246d-2e60-472f-8d30-94b01ef28958
Roberts, G.
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Ziyab, A.H.
288d35a2-e782-49f8-b2e8-fdb0290a7c00
Raza, A.
28cf549d-f7e9-4f43-b60e-8c7866cb1d1d
Karmaus, W.
d78616d6-bc9c-4664-a461-7c0d0be5e39e
Tongue, N.
f370229f-98f1-4a21-8232-a0a4efd82ec6
Zhang, H.
49b0dd51-9e3e-4c73-ac6f-af1bd3a9bcd0
Matthews, S.
79b68905-6033-4cf8-8a36-af956611f854
Arshad, S.H.
917e246d-2e60-472f-8d30-94b01ef28958
Roberts, G.
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3

Ziyab, A.H., Raza, A., Karmaus, W., Tongue, N., Zhang, H., Matthews, S., Arshad, S.H. and Roberts, G. (2010) Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort study. Clinical & Experimental Allergy, 40 (12), 1776-1784. (doi:10.1111/j.1365-2222.2010.03633.x). (PMID:21059120)

Record type: Article

Abstract

Background: trends in the prevalence of eczema in the course of childhood and adolescence are not clear although often a net remission during childhood is assumed.

Objectives: to investigate the dynamics of change in eczema from 1 to 18 years in a prospective study and to understand the influence of gender and atopy.

Methods: detailed information regarding eczema were collected at ages 1, 2, 4, 10 and 18 years from the 1989 Isle of Wight birth cohort (n=1456). Skin prick testing was performed at 4, 10 and 18 years of age. The 12-month period prevalence, positive and negative transitions (defined as change in disease status in two consecutive study assessments) were stratified by gender and atopic status.

Results: the period prevalence of eczema from birth to 18 years of age remained relatively constant (11.9–14.2%) with minimal remission. Up to 10 years of age, gender did not influence prevalence. From 10 to 18 years, eczema became more prevalent among girls (16.3% for girls vs. 8.3% for boys, P<0.001) as a result of a greater positive transition in girls (9.4% for girls vs. 4.3% for boys, P=0.001) and greater negative transition in boys (65.4% for boys vs. 50% for girls, P=0.04). The higher positive transition of eczema in girls was most pronounced for non-atopic eczema (5.9% for girls vs. 1.5% for boys, P=0.002).

Conclusions: we found only a minimal reduction in the prevalence of eczema during childhood and adolescence. During adolescence, more girls develop eczema and more boys outgrow it suggesting a role for gender-specific pubertal factors

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More information

e-pub ahead of print date: 9 November 2010
Published date: December 2010
Organisations: Infection Inflammation & Immunity

Identifiers

Local EPrints ID: 180687
URI: http://eprints.soton.ac.uk/id/eprint/180687
ISSN: 0954-7894
PURE UUID: fcc9fe77-b252-425c-8df6-eca565fcce08
ORCID for G. Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 12 Apr 2011 14:32
Last modified: 15 Mar 2024 03:22

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Contributors

Author: A.H. Ziyab
Author: A. Raza
Author: W. Karmaus
Author: N. Tongue
Author: H. Zhang
Author: S. Matthews
Author: S.H. Arshad
Author: G. Roberts ORCID iD

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