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Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes

Record type: Article

A radiolabeling method for bioconjugation based on the
Diels–Alder reaction between 3,6-diaryl-s-tetrazines and an
18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

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Citation

Li, Zibo, Cai, Hancheng, Hassink, Matthew, Blackman, Melissa L., Brown, Richard C.D., Conti, Peter S. and Fox, Joseph M. (2010) Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes Chemical Communications, 46, (42), pp. 8043-8045. (doi:10.1039/C0cc03078c). (PMID:20862423).

More information

Published date: 2010
Organisations: Chemistry

Identifiers

Local EPrints ID: 180733
URI: http://eprints.soton.ac.uk/id/eprint/180733
ISSN: 1359-7345
PURE UUID: 15385c95-a270-4efb-bf6a-9ec96687220d
ORCID for Richard C.D. Brown: ORCID iD orcid.org/0000-0003-0156-7087

Catalogue record

Date deposited: 12 Apr 2011 08:27
Last modified: 18 Jul 2017 12:00

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Contributors

Author: Zibo Li
Author: Hancheng Cai
Author: Matthew Hassink
Author: Melissa L. Blackman
Author: Peter S. Conti
Author: Joseph M. Fox

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