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Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes

Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes
Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes
A radiolabeling method for bioconjugation based on the
Diels–Alder reaction between 3,6-diaryl-s-tetrazines and an
18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.
1359-7345
8043-8045
Li, Zibo
0604994f-743a-4cad-b628-29d4a41b18f8
Cai, Hancheng
6d75bf35-4c96-4af4-9e82-dbfcbcebd24c
Hassink, Matthew
575de4b1-4b13-4d3c-9caf-319c10ba9ca6
Blackman, Melissa L.
56e8a35f-b363-407d-aaad-371cb949db85
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Conti, Peter S.
f6b720e0-5d07-484e-a907-f487809f364e
Fox, Joseph M.
8cad3f9a-a4db-4cbf-96d0-6f38af662532
Li, Zibo
0604994f-743a-4cad-b628-29d4a41b18f8
Cai, Hancheng
6d75bf35-4c96-4af4-9e82-dbfcbcebd24c
Hassink, Matthew
575de4b1-4b13-4d3c-9caf-319c10ba9ca6
Blackman, Melissa L.
56e8a35f-b363-407d-aaad-371cb949db85
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Conti, Peter S.
f6b720e0-5d07-484e-a907-f487809f364e
Fox, Joseph M.
8cad3f9a-a4db-4cbf-96d0-6f38af662532

Li, Zibo, Cai, Hancheng, Hassink, Matthew, Blackman, Melissa L., Brown, Richard C.D., Conti, Peter S. and Fox, Joseph M. (2010) Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes. Chemical Communications, 46 (42), 8043-8045. (doi:10.1039/C0cc03078c). (PMID:20862423)

Record type: Article

Abstract

A radiolabeling method for bioconjugation based on the
Diels–Alder reaction between 3,6-diaryl-s-tetrazines and an
18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

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More information

Published date: 2010
Organisations: Chemistry

Identifiers

Local EPrints ID: 180733
URI: http://eprints.soton.ac.uk/id/eprint/180733
ISSN: 1359-7345
PURE UUID: 15385c95-a270-4efb-bf6a-9ec96687220d
ORCID for Richard C.D. Brown: ORCID iD orcid.org/0000-0003-0156-7087

Catalogue record

Date deposited: 12 Apr 2011 08:27
Last modified: 26 Nov 2019 01:59

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