Li, Zibo, Cai, Hancheng, Hassink, Matthew, Blackman, Melissa L., Brown, Richard C.D., Conti, Peter S. and Fox, Joseph M.
Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes
Chemical Communications, 46, (42), . (doi:10.1039/C0cc03078c). (PMID:20862423).
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A radiolabeling method for bioconjugation based on the
Diels–Alder reaction between 3,6-diaryl-s-tetrazines and an
18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.
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