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Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes

Li, Zibo, Cai, Hancheng, Hassink, Matthew, Blackman, Melissa L., Brown, Richard C.D., Conti, Peter S. and Fox, Joseph M. (2010) Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes Chemical Communications, 46, (42), pp. 8043-8045. (doi:10.1039/C0cc03078c). (PMID:20862423).

Record type: Article


A radiolabeling method for bioconjugation based on the
Diels–Alder reaction between 3,6-diaryl-s-tetrazines and an
18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

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Published date: 2010
Organisations: Chemistry


Local EPrints ID: 180733
ISSN: 1359-7345
PURE UUID: 15385c95-a270-4efb-bf6a-9ec96687220d
ORCID for Richard C.D. Brown: ORCID iD

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Date deposited: 12 Apr 2011 08:27
Last modified: 18 Jul 2017 12:00

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Author: Zibo Li
Author: Hancheng Cai
Author: Matthew Hassink
Author: Melissa L. Blackman
Author: Peter S. Conti
Author: Joseph M. Fox

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