Synthesis and derivatisation of a novel spiro [1-benzofuran-2,4'-piperidin] -3-one scaffold
Synthesis and derivatisation of a novel spiro [1-benzofuran-2,4'-piperidin] -3-one scaffold
The synthesis of a novel spiro[1-benzofuran-2,4'-piperidin]-3-one scaffold 6 has been achieved in five steps with an overall yield of 47%. The versatility of the spiropiperidine scaffold in the context of library synthesis is exemplified by selective and sequential derivatisation of the amino and aryl bromide functional groups, including the development of multi-step telescope reaction matrices.
drug discovery, privileged structures, combinatorial libraries, design, potent, substructures, antagonists, diversity, phase, scope
3228-3235
Wilson, Rowan A.
f8d47839-13c1-4611-8c6e-42e55ef198b9
Chan, Lai
ecd3b799-22f3-41d5-9de5-e4c73556d581
Wood, Robin
331d6e70-16d1-42ce-aeac-89a77a51b163
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
2005
Wilson, Rowan A.
f8d47839-13c1-4611-8c6e-42e55ef198b9
Chan, Lai
ecd3b799-22f3-41d5-9de5-e4c73556d581
Wood, Robin
331d6e70-16d1-42ce-aeac-89a77a51b163
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Wilson, Rowan A., Chan, Lai, Wood, Robin and Brown, Richard C.D.
(2005)
Synthesis and derivatisation of a novel spiro [1-benzofuran-2,4'-piperidin] -3-one scaffold.
Organic & Biomolecular Chemistry, 3 (17), .
(doi:10.1039/B507339A).
(PMID:16106306)
Abstract
The synthesis of a novel spiro[1-benzofuran-2,4'-piperidin]-3-one scaffold 6 has been achieved in five steps with an overall yield of 47%. The versatility of the spiropiperidine scaffold in the context of library synthesis is exemplified by selective and sequential derivatisation of the amino and aryl bromide functional groups, including the development of multi-step telescope reaction matrices.
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Published date: 2005
Keywords:
drug discovery, privileged structures, combinatorial libraries, design, potent, substructures, antagonists, diversity, phase, scope
Organisations:
Chemistry
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Local EPrints ID: 180745
URI: http://eprints.soton.ac.uk/id/eprint/180745
ISSN: 1477-0520
PURE UUID: b46f3b9d-c0bd-4523-a8bd-68c58adea28d
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Date deposited: 12 Apr 2011 09:14
Last modified: 15 Mar 2024 02:53
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Contributors
Author:
Rowan A. Wilson
Author:
Lai Chan
Author:
Robin Wood
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