Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatment
Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatment
Objective: To test the hypothesis that: (i) functional microvascular dilator capacity is independently associated with insulin sensitivity and age in individuals with central adiposity at risk of cardiovascular disease (CVD); and (ii) functional microvascular dilator capacity is improved by high dose statin treatment.
Methods: Functional dilator capacity (measured as change in laser Doppler blood flux from baseline during post occlusive reactive hyperemia [peak flux%resting flux; PF%RF] and flowmotion (power spectral density [PSD] analysis)) were assessed in 40 people with central adiposity and one or more other CVD risk factors. Measurements were made at rest and during acute hyperinsulinaemia before and six months after high dose atorvastatin (40 mg daily) or placebo.
Results: Insulin-induced change in PF%RF was independently associated with insulin sensitivity (M/I) (r = 0.46 p = 0.02) and age (r = ?0.46 p = 0.02), which together explained almost half of the variance in PF%RF (adjusted r2 = 0.37, p = 0.008). Whilst atorvastatin decreased LDL cholesterol by 51% (p < 0.001), PF%RF and flowmotion remained unchanged.
Conclusions: Insulin sensitivity and age are independently associated with an insulin-induced change in functional microvascular dilator capacity in individuals with central adiposity at risk of CVD. Dilator capacity is not improved by six months high dose statin treatment
74-84
Clough, Geraldine
9f19639e-a929-4976-ac35-259f9011c494
L'Esperance, Veline
0d44b963-1287-432c-9913-b106064551ce
Turzyniecka, Magdalena Joanna
8368c46e-6803-4750-b56c-518ea1fbf871
Walter, Lara
eaf77899-5915-4f62-9996-bab7676069ae
Chipperfield, Andrew
524269cd-5f30-4356-92d4-891c14c09340
Gamble, John
2e45ff40-aab3-4fca-b553-1f5bcff68ffe
Krentz, A.J.
e2c541b2-1292-4cf1-bc0c-d06f3242156d
Byrne, Christopher D
1370b997-cead-4229-83a7-53301ed2a43c
23 December 2010
Clough, Geraldine
9f19639e-a929-4976-ac35-259f9011c494
L'Esperance, Veline
0d44b963-1287-432c-9913-b106064551ce
Turzyniecka, Magdalena Joanna
8368c46e-6803-4750-b56c-518ea1fbf871
Walter, Lara
eaf77899-5915-4f62-9996-bab7676069ae
Chipperfield, Andrew
524269cd-5f30-4356-92d4-891c14c09340
Gamble, John
2e45ff40-aab3-4fca-b553-1f5bcff68ffe
Krentz, A.J.
e2c541b2-1292-4cf1-bc0c-d06f3242156d
Byrne, Christopher D
1370b997-cead-4229-83a7-53301ed2a43c
Clough, Geraldine, L'Esperance, Veline, Turzyniecka, Magdalena Joanna, Walter, Lara, Chipperfield, Andrew, Gamble, John, Krentz, A.J. and Byrne, Christopher D
(2010)
Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatment.
International Journal of Microcirculation, 18 (1), .
(doi:10.1111/j.1549-8719.2010.00070.x).
(PMID:21166928)
Abstract
Objective: To test the hypothesis that: (i) functional microvascular dilator capacity is independently associated with insulin sensitivity and age in individuals with central adiposity at risk of cardiovascular disease (CVD); and (ii) functional microvascular dilator capacity is improved by high dose statin treatment.
Methods: Functional dilator capacity (measured as change in laser Doppler blood flux from baseline during post occlusive reactive hyperemia [peak flux%resting flux; PF%RF] and flowmotion (power spectral density [PSD] analysis)) were assessed in 40 people with central adiposity and one or more other CVD risk factors. Measurements were made at rest and during acute hyperinsulinaemia before and six months after high dose atorvastatin (40 mg daily) or placebo.
Results: Insulin-induced change in PF%RF was independently associated with insulin sensitivity (M/I) (r = 0.46 p = 0.02) and age (r = ?0.46 p = 0.02), which together explained almost half of the variance in PF%RF (adjusted r2 = 0.37, p = 0.008). Whilst atorvastatin decreased LDL cholesterol by 51% (p < 0.001), PF%RF and flowmotion remained unchanged.
Conclusions: Insulin sensitivity and age are independently associated with an insulin-induced change in functional microvascular dilator capacity in individuals with central adiposity at risk of CVD. Dilator capacity is not improved by six months high dose statin treatment
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Accepted/In Press date: 3 November 2010
e-pub ahead of print date: 10 November 2010
Published date: 23 December 2010
Additional Information:
© 2010 John Wiley & Sons Ltd
Identifiers
Local EPrints ID: 181121
URI: http://eprints.soton.ac.uk/id/eprint/181121
ISSN: 0167-6865
PURE UUID: cd375ed0-5527-4507-bd4a-f5a25ce31e84
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Date deposited: 15 Apr 2011 10:42
Last modified: 15 Mar 2024 03:15
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Contributors
Author:
Veline L'Esperance
Author:
Magdalena Joanna Turzyniecka
Author:
Lara Walter
Author:
John Gamble
Author:
A.J. Krentz
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